Yale Scientists Visualize Molecular Detail Of RNA Splicing Complex

Scientists in the department of molecular biophysics and biochemistry at Yale revealed the crystal structure of the first described enzymatic RNA - what it looks like and how it reacts - in the journal Nature. Scott Strobel, professor and principal investigator of the study and his research team at Yale, used X-ray crystallography to image the self-splicing group-I intron and the associations it makes as it reacts. The image shows an interaction with metal ions and the alignment of the RNA molecule segments.

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