University of Pennsylvania School of Medicine Researchers Discover Link Between Chronic Kidney Disease and Oxygen-Deprived Tissue

PHILADELPHIA- Researchers at the University of Pennsylvania School of Medicine have discovered how low-oxygen conditions can worsen chronic kidney disease (CKD). The key player is a protein called hypoxia-inducible-factor (HIF-1) that, as its name suggests, is active when the kidney does not get enough oxygen, a condition known as hypoxia. The findings appear in a December issue of the Journal of Clinical Investigation.

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