‘Dynamic Imaging System’ Nets Yale University Scientist the 2014 STEM CELLS’ Young Investigator Award

Durham, NC – Shangqin Guo, Ph.D., a scientist at Yale University, is the recipient of the 2014 STEM CELLS’ Young Investigator Award. The award is presented to a young researcher who serves as principal author of a significant study published in the journal over the past year.

The paper that earned Dr. Guo this recognition is “Dynamic Migration and Cell-Cell Interactions of Early Reprogramming Revealed by High Resolution Time-Lapse Imaging,” published in STEM CELLS’ May 2013 issue. It describes a live cell imaging approach for studying the process of Yamanaka reprogramming at single cell resolution. It also reports on the unexpected dynamic behaviors associated with early reprogramming and explores how such behaviors could compromise conventional experimental designs and interfere with data interpretation.

Jan A. Nolta, Ph.D., editor-in-chief of STEM CELLS, commented on Dr. Guo’s award. “There are still many questions about how cells can be most effectively reprogrammed back to pluripotency and what steps occur during this process,” she said. “The outstanding study by Dr. Guo’s laboratory created a dynamic imaging system that was used to address multiple key questions regarding early reprogramming from hematopoietic cells.

“The studies show the importance of cell-to-cell contact through ‘dumbbell structures’ after early divisions and identify E-cadherin as a key regulator. The use of the imaging and new technology in this study is truly elegant, and I congratulate our Young Investigator Award winner on this important accomplishment,“ she added.

Dr. Guo currently is assistant professor in the Department of Cell Biology at Yale University. Her lab at the Yale Stem Cell Center focuses on learning the cell fate decision processes including how does a cell know what to be and what not to be?

“For someone who is just starting off, this provides a sense of reassurance, recognition and gratification,” she said about receiving the award.


Full Citation:

Megyola, C. M., Gao, Y., Teixeira, A. M., Cheng, J., Heydari, K., Cheng, E.-C., Nottoli, T., Krause, D. S., Lu, J. and Guo, S. (2013), Dynamic Migration and Cell-Cell Interactions of Early Reprogramming Revealed by High-Resolution Time-Lapse Imaging. STEM CELLS, 31: 895–905. doi: 10.1002/stem.1323

Paper URL: http://onlinelibrary.wiley.com/doi/10.1002/stem.1323/full


STEM CELLS, a peer reviewed journal published monthly, provides a forum for prompt publication of original investigative papers and concise reviews. The journal covers all aspects of stem cells: embryonic stem cells/induced pluripotent stem cells; tissue-specific stem cells; cancer stem cells; the stem cell niche; stem cell epigenetics, genomics and proteomics; and translational and clinical research. STEM CELLS is co-published by AlphaMed Press and Wiley.

About AlphaMed Press:

Established in 1983, AlphaMed Press with offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, publishes three internationally renowned peer-reviewed journals with globally recognized editorial boards dedicated to advancing knowledge and education in their focused disciplines. STEM CELLS® (www.StemCells.com) is the world's first journal devoted to this fast paced field of research. The Oncologist® (www.TheOncologist.com) is devoted to community and hospital-based oncologists and physicians entrusted with cancer patient care. STEM CELLS TRANSLATIONAL MEDICINE® (www.StemCellsTM.com) is dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology.

About Wiley:

Founded in 1807, John Wiley & Sons, Inc. has been a valued source of information and understanding for more than 200 years, helping people around the world meet their needs and fulfill their aspirations. Wiley and its acquired companies have published the works of more than 450 Nobel laureates in all categories: Literature, Economics, Physiology or Medicine, Physics, Chemistry, and Peace.

Wiley is a global provider of content and content-enabled workflow solutions in areas of scientific, technical, medical, and scholarly research; professional development; and education. Our core businesses produce scientific, technical, medical, and scholarly journals, reference works, books, database services, and advertising; professional books, subscription products, certification and training services and online applications; and education content and services including integrated online teaching and learning resources for undergraduate and graduate students and lifelong learners. Wiley's global headquarters are located in Hoboken, New Jersey, with operations in the U.S., Europe, Asia, Canada, and Australia. The Company's Web site can be accessed at http://www.wiley.com. The Company is listed on the New York Stock Exchange under the symbols JWa and JWb.

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