Sarepta Therapeutics (SRPT) Enters Into Partnership With Flagship Biosciences LLC To Digitally Automate The Measurement Of Dystrophin, A Key Therapeutic Efficacy Marker For Muscular Dystrophy
8/21/2014 10:44:58 AM
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Sarepta Therapeutics, Inc., a developer of innovative RNA-based therapeutics, and Flagship Biosciences LLC, a leading tissue-based companion diagnostics firm, today announced a multi-year, multi-product partnership for the development of automated quantitative endpoint measurements in muscular dystrophy to support the advancement of Sarepta’s Duchenne muscular dystrophy (DMD) drug pipeline, including its lead candidate, eteplirsen.
DMD is caused by the absence of functional dystrophin in affected patients’ muscle tissue. Dystrophin protein level is a fundamental biomarker used to assess therapies that aim to produce and restore the expression of dystrophin, such as exon-skipping therapies like eteplirsen. In order to optimally and efficiently evaluate therapeutic efficacy in patients, the next generation of protocols are being developed to digitally automate and standardize dystrophin measurement in tissue biopsies to speed the process while ensuring consistency. The establishment of these new standardized methods for automated quantitation is being enabled though the proprietary image analysis platform and digital pathology capabilities developed by Flagship.
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