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Fluidigm Corporation And Broad Institute Release: Single-Cell Mrna Sequencing Helps Reveal The Role Of “Precocious” Dendritic Cells In Inflammatory Response


6/30/2014 10:19:25 AM

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BOSTON & SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--In work published in Nature this month, scientists at the Broad Institute and Fluidigm Corporation used the C1TM Single-Cell Auto Prep System to prepare cells for single-cell sequencing - enabling the discovery of a subpopulation of “precocious” cells expressing antiviral genes earlier than the majority of dendritic cells exposed to the same antigen. Normally, the ability to detect the actions of these “precocious expresser” cells would be lost due to averaging across many millions of cells in bulk cell studies. With this discovery, made possible with contributions from the Single-Cell Genomics initiative of Fluidigm and the Broad, researchers will be able to explore how these “precocious” cells escalate the body’s immune response when the body is under attack.

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