Karyopharm Therapeutics (KPTI) Announces First Combination Data Of Selinexor With Low-Dose Dexamethasone In Heavily Pretreated Multiple Myeloma Patients
6/13/2014 8:14:08 AM
NATICK, Mass., June 13, 2014 (GLOBE NEWSWIRE) -- Karyopharm Therapeutics Inc. (Nasdaq:KPTI), a clinical-stage pharmaceutical company, today announced initial Phase 1 data from patients with multiple myeloma treated with Karyopharm's lead selective inhibitor of nuclear export (SINE), Selinexor (KPT-330), in combination with "low-dose" (20 mg twice weekly) dexamethasone. Among eight patients, the best responses were one stringent complete response (sCR), three partial responses (PRs), two minor responses (MRs), one progressive disease and one non-evaluable. Accordingly, the clinical benefit response rate (sCR+PR+MR) is 75% and the overall response rate (sCR+PR) is 50%. These new results will be reported at the 19th Congress of the European Hematology Association (EHA) in a poster presentation on Saturday, June 14th from 5:45 – 7:00 PM CEST (Abstract #5580).
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