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Dutch Biotech arGEN-X Plans To Go Public In Brussels


6/10/2014 7:26:33 AM

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arGEN-X Announces Intention To Launch An Initial Public Offering On Euronext Brussels

Breda, the Netherlands / Ghent, Belgium, 10 June 2014 – arGEN - X , a clinical - stage biopharmaceutical company focused on creating and developing differentiated therapeutic antibodies for the treatment of cancer and severe autoimmune diseases, today announced its intention to rais e new funds through an Initial Public Offering on Euronext Brussels.

Company highlights :

P ipelin e of highly differentiated clinical and preclinical antibody candidates

arGEN - X ’ lead antibody development candidates are:

* ARGX - 110: a SIMPLE Antibody ™ targeting CD70, a n immune checkpoint target involved in hematological malignancies (lymphomas and leuke mias) , several solid tumors and severe autoimmune diseases. ARGX - 110 works in three ways: i) block s growth of tumor cells, ii) kill s cancer cells and iii) activate s the patients’ immune system against the tumor. ARGX - 110 is currently being evaluated across a range of hematological and solid tumors in a Phase 1b study in Europ e and will be developed in a Phase 2 trial in sponsorship with the Leukemia & Lymphoma Society for the rare lymphoma Waldenström’s macroglobulinemia .

* ARGX - 111: a SIMPLE Antibody ™ targeting c - Met, a receptor involved in cancer spread (metastasis) in both solid and hematological tumors. ARGX - 111 binds to a unique site on c - Met resulting in its deactivation, with the aim to prevent the spread of tumor cells. It is equipped to kill t umor cells and is enhanced to increase tissue penetration . ARGX - 111 is being evaluated in a European Phase 1 b clinical study across a range of hematological and solid tumors.

* ARGX - 113: an antibody fragment that has been designed to rapidly remove pathogen ic autoantibodies implicated in diverse severe autoimmune diseases. ARGX - 113 is in late preclinical development

Clinical development strategy targeting orphan indications, in support of partnering for major indications

arGEN - X ’ clinical development strateg y is to advance the preclinical and clinical development of its antibody candidates in rare/orphan diseases, which is expected to rapidly yield clinical data to support partnering of these candidates in major indications.

Strategic collaborations with industry partners

a rGEN - X is looking to build a select number of deep strategic partnerships with reputable industry players. The company has established a global strategic alliance with Shire Pharmaceuticals, as well as part nerships with Bayer AG, Boehringer Ingelheim and RuiYi . These partnerships could yield over € 1. 3 billion in potential cumulative future revenue to a rGEN - X , subject to meeting specific development and sales milestone events and developing the total possible number of targets , calculated before royalties on product sales.

Suite of innovative and complementary antibody technology platforms yielding therapeutic antibodies with multiple modes of action against novel and complex targets

SIMPLE Antibody™, arGEN - X’ flagship discovery platform, leverages the power of the llama immune system to address novel complex disease targets often difficult to access with established antibody technologies. Differentiated therapeutic qualities a nd multiple modes of action are added through complementary Fc engineering technologies – NHance®, ABDEG™ and POTELLIGENT®.

a rGEN - X was incorporated in 2008, and has its main operations and state of the art research facilities in Ghent, Belgium. It is bac ked by leading US and European life sciences investors and its s enior leadership team consists of experienced industry professionals with highly complementary skills and a long and successful track record in antibody drug discovery , development and commerc ialization . The I nitial P ublic O ffering is expected to consist of an offering of new shares . a rGEN - X envisage s apply ing for a list ing on Euronext Brussels. KBC Securities and Kempen & Co are acting as Joint Global Coordinators and Joint Bookrunners with Petercam a s Co - Lead M anager , and Wedbush PacGrow Life Sciences as Selling A gent .

www.argen-x.com

SIMPLE Antibody™, NHance® and ABDEG™ are trademarks of a rGEN - X N . V . POTELLIGENT® is a trademark of BioWa, Inc.

For further information, please contact:

Tim Van Hauwermeiren , CEO
Eric Castaldi , CFO
+32 (0)9 243 40 70

Mark Swallow/David Dible
Citigate Dewe Rogerson
+44 207 282 2949

The information contained in this announcement is for background purposes only and does not purport to be full or complete.

KBC Securities, Kempen & Co, Petercam and Wedbush PacGrow Life Sciences are acting for a rGEN - X and no one else in relation to th e Initial Public Offering, and will not be responsible to anyone other than a rGEN - X for providing the protections offered to their respective clients nor for providing advice in relation to the Initial Public Offering.

a rGEN - X assumes responsibility for t he information contained in this announcement. None of KBC Securities, Kempen & Co, Petercam or Wedbush PacGrow Life Sciences or any of their respective directors, officers, employees, advisers or agents accepts any responsibility or liability whatsoever f or or makes any representation or warranty, express or implied, as to the truth, accuracy or completeness of the information in this announcement (or whether any information has been omitted from the announcement) or any other information relating to a rGEN - X its respective subsidiaries or associated companies, whether written, oral or in a visual or electronic form, and howsoever transmitted or made available or for any loss howsoever arising from any use of announcement or its contents or otherwise arising in connection therewith.

No representation or warranty, express or implied, is given by or on behalf of a rGEN - X or any of its affiliates as to the accuracy or completeness of the information or opinions contained in this announcement, and no liability is accepted for any such information or opinions.

This announcement does not constitute, or form part of, an offer or invitation to sell or issue, or any solicitation of an offer to purchase securities and any purchase of, or application for, shares in a rG EN - X to be sold in connection with the Initial Public Offering should only be made on the basis of information contained in the prospectus to be issued in due course in connection with the Initial Public Offering and any supplements thereto. The prospectus will contain certain detailed information about arGEN - X and its business, management, risks associated with investing in ArGEN - X, as well as financial statements and other financial data.

This announcement does not constitute or form part of an offer or solicitation to purchase or subscribe for new shares in the capital of arGEN - X in the United States, Australia, Canada, Japan or any jurisdiction in which such an offer or solicitation is unlawful. In particular, the new shares referred to in this Announce ment have not been, and will not be, registered under the U.S. Securities Act of 1933 (the “Securities Act”) or under the securities legislation of any state of the United States, and may not be offered, sold, resold or delivered, directly or indirectly, i n or into the United States absent registration except pursuant to an exemption from, or in a transaction not subject to, the registration requirements of the Securities Act. No public offering of securities of arGEN - X will be made in connection with the Initial Public Offering in the United States, Australia, Canada, Japan or elsewhere.

This communication is directed only at (i) persons who are outside the United Kingdom or (ii) persons who have professional experience in matters relating to investments falling within Article 19(5) of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2005 (the “Order”) and (iii) high net worth entities, and other persons to whom it may lawfully be communicated, falling within Article 49(2) (A) to (D) of the Order (all such persons together being referred to as “relevant persons”). Any investment activity to which this communication relates will only be available to and will only be engaged in with, relevant persons. Any person who is not a relevant person should not act or rely on this document or any of its contents.

This communicat ion may be distributed in a member state of the European Economic Area, with the exception of Belgium, which applies Directive 2003/71/EC and amendments thereto, including Directive 2010/73/EU (this Directive together with any implementing measures in any member state, the “Prospectus Directive”) only to those persons who are investment professionals for the purposes of the Prospectus Directive in such member state, and such other persons as this document may be addressed on legal grounds, and no person tha t is not a relevant person may act or rely on this document or any of its contents.

The contents of this announcement include statements that are, or may be deemed to be, "forward - looking statements". These forward - looking statements can be identified by the use of forward - looking terminology, including the terms "believes", "estimates", "anticipates", "expects", "intends", "may", "will", or "should", and include statements arGEN - X makes concerning the intended results of its strategy. By their nature, fo rward - looking statements involve risks and uncertainties and readers are cautioned that any such forward - looking statements are not guarantees of future performance. a rGEN - X ’ actual results may differ materially from those predicted by the forward - looking statements. arGEN - X undertakes no obligation to publicly update or revise forward - looking statements, except as may be required by law.

Each of a rGEN - X, KBC Securities, Kempen & Co, Petercam and Wedbush PacGrow Life Sciences and their respective affiliate s expressly disclaims any obligation or undertaking to update, review or revise any forward -looking statement contained in this announcement whether as a result of new information, future developments or otherwise.

The date of listing on Euronext Brussel s may be influenced by things such as market conditions. There is no guarantee that such listing will occur and you should not base your financial decisions on the a rGEN - X intentions in relation to such listing at this stage. Acquiring investments to which this announcement relates may expose an investor to a significant risk of losing the entire amount invested. Persons considering such investments should consult an authorised person specialising in advising on such investments. This announcement does not constitute a recommendation concerning the offering. The value of the shares can decrease as well as increase. Potential investors should consult a professional advisor as to the suitability of the offering for the person concerned.

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