News | News By Subject | News by Disease News By Date | Search News
Get Our FREE
Industry eNewsletter
email:    
   

Agios Pharmaceuticals (AGIO) Initiates Multiple Ascending Dose Trial In Healthy Volunteers Of AG-348 For The Potential Treatment Of PK Deficiency, A Rare, Hemolytic Anemia


6/9/2014 8:32:00 AM

free biotech news Get the latest biotech news where you want it. Sign up for the free GenePool newsletter today!

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Agios Pharmaceuticals, Inc. (NASDAQ: AGIO), a leader in the fields of cancer metabolism and inborn errors of metabolism (IEMs), today announced the initiation of a multiple ascending dose (MAD) Phase 1 trial of AG-348 in healthy volunteers. This study is designed to characterize the safety, tolerability, pharmacokinetics and pharmacodynamics of increasing doses of AG-348 for 14 days. AG-348 is a novel, first-in-class, orally available activator of pyruvate kinase-R (PKR) for the treatment of pyruvate kinase (PK) deficiency, a rare, hemolytic anemia. This trial was initiated based on data from the ongoing single ascending dose (SAD) Phase 1 trial, in which AG-348 has been determined to be well tolerated to date. The SAD study began in April 2014 and has completed dosing of more than half of the planned cohorts. Data from both studies are expected to be presented at a medical conference in 2015.

Help employers find you! Check out all the jobs and post your resume.

Read at BioSpace.com

comments powered by Disqus
   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES