TetraLogic Pharmaceuticals (TLOG) Announces Selection Of Phase 2 Dose For Randomized Clinical Study Of Birinapant In Combination With Azacitidine In Naive Patients With Higher Risk Myelodysplastic Syndromes (MDS)
5/27/2014 9:20:40 AM
MALVERN, Pa., May 27, 2014 (GLOBE NEWSWIRE) -- TetraLogic Pharmaceuticals Corporation (Nasdaq:TLOG) today announced that, based upon data from its Phase 1b study of birinapant in combination with azacitidine in patients with relapsed/refractory or naïve higher risk MDS, it selected a dose of 13mg/m2 twice weekly for three weeks out of four to be used in its Phase 2 clinical trial. The primary objective of the Phase 1b clinical study is to characterize the safety and tolerability and determine the recommended phase 2 dose of birinapant when administered in combination with azacitidine. Additional objectives of the study are to assess any preliminary indications of efficacy and pharmacodynamics of the combination.
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