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Gene Family That Suppresses Prostate Cancer Discovered, Cornell University Study


3/14/2014 6:28:15 AM

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Cornell researchers report they have discovered direct genetic evidence that a family of genes, called MicroRNA-34 (miR-34), are bona fide tumor suppressors. The study is published in the journal Cell Reports, March 13. Previous research at Cornell and elsewhere has shown that another gene, called p53, acts to positively regulate miR-34. Mutations of p53 have been implicated in half of all cancers. Interestingly, miR-34 is also frequently silenced by mechanisms other than p53 in many cancers, including those with p53 mutations.

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