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Merck & Co., Inc. (MRK)'s Investigational HIV Therapy, Doravirine (MK-1439), Demonstrates Antiviral Activity In Phase 2B Study Of Treatment-Naïve Adults


3/5/2014 10:54:23 AM

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by Richard Daverman, PhD

BOSTON, Mar 05, 2014 (BUSINESS WIRE) -- Merck MRK -0.25% , known as MSD outside the United States and Canada, today presented data from the dose-ranging portion of an ongoing Phase 2B clinical trial of doravirine, the company’s investigational next-generation, non-nucleoside reverse transcriptase inhibitor (NNRTI), at the 21st Conference on Retroviruses and Opportunistic Infections (CROI). Interim data demonstrating potent antiretroviral (ARV) activity for four doses (25, 50, 100 and 200 mg) of once-daily, oral doravirine in combination with tenofovir/emtricitabine in treatment-naïve, HIV-1 infected adults after 24 weeks of treatment were presented during a late-breaker oral session. Based on these findings as well as other data from the doravirine clinical program, Merck plans to initiate a Phase 3 clinical trial program for doravirine in combination with ARV therapy in the second half of 2014.

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