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Is Zinc The Missing Link For Osteoarthritis Therapies? Gwangju Institute of Science and Technology Study


2/14/2014 6:20:47 AM

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Osteoarthritis is a leading cause of disability, characterized by the destruction of cartilage tissue in joints, but there is a lack of effective therapies because the underlying molecular causes have been unclear. A study published by Cell Press February 13th in the journal Cell reveals that osteoarthritis-related tissue damage is caused by a molecular pathway that is involved in regulating and responding to zinc levels inside of cartilage cells. A protein called ZIP8 transports zinc inside these cells, setting off a cascade of molecular events that result in the destruction of cartilage tissue in mice. The findings could lead to a new generation of therapies for osteoarthritis.

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