BioSpace.com

Biotech and Pharmaceutical
News & Jobs
Search the Site
 
   
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
eNewsletter Signup
Miles
Km80.5

   

Eureka Therapeutics Announces License Agreement For Development And Commercialization Of Novel Monoclonal Antibody For Treatment Of Leukemia And Other Cancers


1/30/2014 8:47:49 AM

free biotech news Get the latest biotech news where you want it. Sign up for the free GenePool newsletter today!

January 28, 2014 EMERYVILLE, CA -- Eureka Therapeutics and Memorial Sloan-Kettering Cancer Center announced that they have entered into a license agreement with Novartis for the development and commercialization of ESK1, a preclinical-stage monoclonal antibody for the treatment of leukemia and other cancers. The antibody was developed under a collaborative effort between Eureka Therapeutics and Memorial Sloan-Kettering Cancer Center.

Unlike other human therapeutic monoclonal antibodies, which can only target proteins that remain on the outside of cancer cells, ESK1 targets WT1, a protein that resides on the inside of the cell. WT1 is overexpressed in a range of leukemias and other cancers including myeloma and breast, ovarian, and colorectal cancers. ESK1 was engineered to mimic the functions of a T cell receptor, a key component of the immune system. As proteins inside the cell get broken down as part of regular cellular processes, fragments of those proteins are carried to the cell surface. When T cells recognize these fragments as abnormal, through T cell receptors, the T cell kills the diseased cell.

"This partnership highlights how academia, biotech and pharma companies can work together to bring innovative cancer treatments to patients,” said Cheng Liu, President and CEO of Eureka Therapeutics. “The success of ESK1 would be a game-changer for the field of antibody therapeutics. It would validate the use of monoclonal antibodies against intracellular antigens, formerly thought to be ‘undruggable’ targets."

Under the terms of the agreement, Eureka Therapeutics and Memorial Sloan-Kettering grant Novartis an exclusive, world-wide license to develop ESK1 for all indications. In return, Eureka Therapeutics and Memorial Sloan-Kettering will receive an up-front payment and potential future payments upon achievement of development, regulatory and sales milestones, and annual net sales royalty payments. Novartis will fund and execute all additional development and commercialization activities.

About Eureka Therapeutics

Eureka Therapeutics is a privately held biotechnology company located in the San Francisco Bay Area, focused on the discovery of fully-human antibody drugs for the treatment of cancer. Utilizing its antibody drug discovery and engineering technologies, Eureka is advancing safe and effective therapies for targeting previously inaccessible cancer antigens. The company has built an early stage pipeline of innovative drugs, with the most advanced candidates at pre-clinical stage in collaboration with Memorial Sloan-Kettering Cancer Center. For more information about Eureka Therapeutics, please visit: www.eurekainc.com.

Contact

Elisa Pan, Head of Business Operations
Eureka Therapeutics, Inc.
5858 Horton Street, Suite 362
Emeryville, CA 94608
510-654-7045
admin@eurekainc.com

Help employers find you! Check out all the jobs and post your resume.


Read at BioSpace.com

 
 

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES