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Drug Developers Seek Extreme Clinical Phenotypes To Ignite Medical Discovery


1/23/2014 8:40:12 AM

free biotech news Get the latest biotech news where you want it. Sign up for the free GenePool newsletter today!

How do you go about discovering new medicines?

You might begin empirically, and look around for something that seems to work — willow bark for pain, for instance, or an anti-tuberculosis pill for depression. This approach relies on what author Morton Meyers calls “happy accidents,” and accounts for a remarkable number of existing therapeutics (most of them, Nassim Taleb asserts). Supporting this seemingly radical conjecture, a 2011 paper in Nature Reviews Drug Discovery reported that between 1999 and 2008, more FDA-approved first-in-class small molecules were derived from phenotypic screening (an empiric approach) than from insight-oriented, target-based drug discovery.

Hey, check out all the research scientist jobs. Post your resume today!


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