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Kolltan Pharmaceuticals Inc. Initiates Phase 1 Study Of KTN3379, A Dual-Mechanism Anti-Erbb3 Monoclonal Antibody



1/21/2014 9:22:17 AM

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NEW HAVEN, Conn.--(BUSINESS WIRE)--Kolltan Pharmaceuticals, a privately held biopharmaceutical company, today announced treatment of the first cancer patient with Kolltan’s lead drug candidate, KTN3379, as part of a Phase 1 clinical study evaluating safety, preliminary evidence of antitumor activity, and pharmacokinetics. KTN3379 is a human monoclonal antibody that blocks the activity of ErbB3, a member of the ErbB family of receptor tyrosine kinases. KTN3379 has a dual mechanism of action that blocks activity of ErbB3 when activated by stimulatory growth factor neuregulin or by other receptor tyrosine kinases (such as ErbB2) in the absence of neuregulin. Currently marketed products, both antibodies and small molecules, that are active against other members of the ErbB family have shown clinical benefit in the treatment of a range of solid tumors, including lung, head and neck, colorectal and breast malignancies. However, there is currently no marketed drug that binds to and inhibits the action of ErbB3.

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