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Scancell Release: Investor Update Showcases Moditope® Platform and Updates SCIB1 Trial Progress
10/1/2013 8:55:45 AM
1 October 2013 -- Scancell Holdings Plc, (AIM:SCLP), the developer of novel immunotherapies for the treatment of cancer, will
today hold an investor update. Following an introduction by Prof. Peter Stern, Institute of Cancer Sciences,
University of Manchester, Dr Richard Goodfellow and Prof Lindy Durrant, Scancell’s joint CEOs will present a
business update as well an overview of the ImmunoBody® platform and SCIB1 clinical programme, including
its current status. A detailed introduction to the new Moditope® platform will also be given for the first time.
Prof Durrant will review the SCIB1 clinical trial programme and confirm that the ongoing studies remain on
track. Further results from this trial are expected by the end of 2013. SCIB1 is Scancell’s first cancer
immunotherapy and is a product of the Company’s ImmunoBody® platform. It is being developed for the
treatment of malignant melanoma and is currently in Phase 1/2 clinical trials. Encouraging results from Part
1 of the study have previously been presented and provide the first clinical evidence that Scancell’s
ImmunoBody® immunotherapy approach is producing an immune response in cancer patients which may
also be associated with clinical benefit. Prof Durrant will today add that four out of the six evaluable patients
treated with either the 2mg or 4mg dose of SCIB1 still remain alive. The mean survival time in this group of
five Stage IV and one Stage IIIb patients is currently 21 months from trial entry.
In view of the positive results and minimal side effects seen with the 4mg dose (Part 1) of the SCIB1 Phase
1/2 trial, the Company has initiated evaluation of an 8mg dose in up to six patients with measurable tumours.
Five patients have been recruited to date: one patient will no longer be evaluable due to delivery of an
incomplete dose of SCIB1 and a further patient was not able to complete dosing within the required
timeframe. A safety review of the data from the 8 mg cohort in Part 1 will be conducted and, if adequate
safety is demonstrated, Scancell plans to recruit a further 10 patients with measurable disease into Part 2 of
the study. An amendment has been submitted to the appropriate regulatory authorities to request approval
to treat these additional patients at the 8 mg dose.
Prof Lindy Durrant, the inventor of the Moditope® platform, will present a detailed overview of the technology
and its potential. She will describe how the technology was used to generate the lead product, SCMod1.
Planning is underway for the preclinical and clinical development of SCMod1 as an immunotherapeutic,
provisionally for the treatment of triple-negative breast cancer, ovarian and endometrial cancers. First-inman
clinical studies are scheduled to start in 2016. Moditope® harnesses CD4+ T cells to eradicate tumours
and represents a new class of immunotherapeutic agents. The platform deploys citrullinated tumourassociated
peptide epitopes to overcome self-tolerance and destroy tumour cells, with no requirement for
blockade inhibitors (for example CTLA4 antibodies and PD-1 inhibitors). It can potentially be expanded to
develop multiple immunotherapeutic agents for different cancers. A broad patent has been filed to protect
this platform and covers the use of multiple tumour-associated modified epitopes for the treatment of cancer.
It will be recalled that the ImmunoBody® platform induces a high avidity CD8+ T cell response to tumour
associated antigens. As the Moditope® platform stimulates a potent CD4+ T cell response to modified selfantigens
both platforms are complementary relying on a response by different classes of T cell for their
therapeutic effect. Thus, in principle, a combination of ImmunoBody® and Moditope® derived therapeutics
may be a powerful approach to the treatment of both early and late stage cancers.
In the second part of the seminar, specialist guest speakers, led by Professor Karol Sikora, Dean of
Medicine at University of Buckingham, Medical Director of CancerPartnersUK and honorary Consultant
Oncologist at Hammersmith Hospital, will form an interactive panel to discuss the increasing importance of
immunotherapy for the treatment of cancer and how Scancell’s technology fits into this emerging landscape.
Dr. Richard Goodfellow, joint CEO of Scancell, commented: “We welcome this opportunity to update
investors following the recent successful fundraising completed in August. The SCIB1 clinical programme
remains on track and further data is expected by the end of 2013. Having now filed and exemplified the
patents covering our Moditope® technology, we can provide more detail on how this second platform
technology has the potential to generate a completely new class of potent and selective immunotherapy
agents and which could have a profound effect on the way that cancer immunotherapies are developed. In
particular, the technology may overcome the immune suppression induced by tumours themselves without
the need for checkpoint blockade inhibitors, thereby allowing activated T cells seek out and kill tumour cells
that would otherwise be hidden from the immune system.
“In view of the short to medium term licensing and partnership potential that both the Moditope® and
Immunobody® programmes now bring to the Company, our strategy requires a more flexible approach.
Whilst we are still fully focused on securing a sale of the business at the earliest opportunity, we will now
consider technology validating and revenue generating deals on each individual platform when and where
appropriate in order to enhance the value of the company when it is sold.”
Dr Richard Goodfellow, Joint CEO
Scancell Holdings Plc
+ 44 (0) 20 7831 3113
Professor Lindy Durrant, Joint CEO
Scancell Holdings Plc
+ 44 (0) 20 7831 3113
Camilla Hume/Stephen Keys Cenkos
+ 44 (0) 20 7397 8900
Mo Noonan / Eleanor Clarke FTI Consulting
+ 44 (0) 20 7831 3113
Scancell is developing novel immunotherapies for the treatment of cancer based on its ImmunoBody® and
Moditope® technology platforms. Scancell’s first ImmunoBody®, SCIB1 is being developed for the treatment
of melanoma and is in Phase 1/2 clinical trials. Preliminary evidence from Part 1 of the study showing that
SCIB1 produced an immune response which might be associated with clinical benefit in patients with
malignant melanoma was released in December 2012.
Scancell’s ImmunoBody® immunotherapies target dendritic cells and stimulate both parts of the cellular
immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic
T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.
Scancell has also identified and patented a series of modified epitopes that stimulate the production of killer
CD4+ T cells that destroy tumours without toxicity. The Directors believe that the Moditope® platform could
play a major role in the development of safe and effective cancer immunotherapies in the future.
Scancell, Immunobody® and Moditope® are trade marks of Scancell Limited.
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