Hotspots Found for Chromosome Gene-Wwapping  
11/29/2007 10:58:44 PM

CAMBRIDGE, Mass. (November 29, 2007) – Crossovers and double-strand DNA breaks do not occur randomly on yeast chromosomes during meiosis, but are greatly influenced by the proximity of the chromosome’s telomere, according to research in the laboratory of Whitehead Fellow Andreas Hochwagen. This work may lead to a better understanding of developmental chromosome abnormalities and birth defects.