University of Cincinnati Medical Center Preclinical Study Links Gene to Brain Aneurysm Formation  
8/7/2007 10:25:36 AM

CINCINNATI—University of Cincinnati (UC) neurovascular researchers have identified a gene that—when suppressed or completely absent—may predispose a person to brain aneurysms. Todd Abruzzo, MD, and his colleagues demonstrated that “knocking out” a gene known as endothelial nitric oxide synthase (NOS-3) in an animal model led to intracranial aneurysm formation in 33 percent of study subjects.