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Sanford-Burnham Medical Research Institute Scientists Identify Key Protein That Modulates Organismal Aging  
8/8/2013 10:08:01 AM

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LA JOLLA, Calif., August 8, 2013 — Scientists at Sanford-­--Burnham Medical Research Institute have identified a key factor that regulates the autophagy process, a kind of cleansing mechanism for cells in which waste material and cellular debris is gobbled up to protect cells from damage, and in turn, modulates aging. The findings, published in Nature Communications today, could lead to the development of new therapies for age-­--related disorders that are characterized by a breakdown in this process.

Malene Hansen, Ph.D., associate professor in Sanford-­--Burnham’s Del E. Webb Center for Neuroscience, Aging and Stem Cell Research, and her team as well as collaborators found a transcription factor—an on/off switch for genes—that induces autophagy in animal models, including the nematode C. elegans, the primary model organism studied in the Hansen lab. This transcription factor, called HLH-­--30, coordinates the autophagy process by regulating genes with functions in different steps of the process. Two years ago, researchers discovered a similar transcription factor, or orthologue, called TFEB that regulates autophagy in mammalian cells.

“HLH-­--30 is critical to ensure longevity in all of the long-­--lived C. elegans strains we tested,” says Hansen. “These models require active HLH-­--30 to extend lifespan, possibly by inducing autophagy. We found this activation not only in worm longevity models, but also in dietary-­--restricted mice, and we propose the mechanism might be conserved in higher organisms as well.”

The research was funded by the National Institutes of Health (P50 AG005131), the National Institute on Aging (F31 AG029222, R01 AG038664, R01 AG039756), the NIGMS (R01 GM101056).

The study was co-­--authored by C. Daniel De Magalhaes Filho, Glenn Center for Aging, Salk Institute for Biological Studies; Philip R. McQuary, Sanford-­-- Burnham; Chu-­--Chiao Chu, Sanford-­--Burnham; Jessica T. Chang, Sanford-­-- Burnham; Sara Gelino, Sanford-­--Burnham; Binnan Ong, Sanford-­--Burnham; Andrew E. Davis, Sanford-­--Burnham; Javier E. Irazoqui, Harvard Medical School; and Andrew Dillin, Glenn Center for Aging, Salk Institute for Biological Studies.

About Sanford-­--Burnham Medical Research Institute

Sanford-­--Burnham Medical Research Institute is dedicated to discovering the fundamental molecular causes of diseases and devising the innovative therapies of tomorrow. Sanford-­--Burnham takes a collaborative approach to medical research with major programs in cancer, neurodegeneration, diabetes, and infectious, inflammatory and childhood diseases. The Institute is recognized for its National Cancer Institute-­--designated Cancer Center and expertise in drug discovery technologies. Sanford-­--Burnham is a nonprofit, independent institute that employs 1,200 scientists and staff in San Diego (La Jolla), California, and Orlando (Lake Nona), Florida. For more information, visit us at www.sanfordburnham.org.

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