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MethylGene Announces Plan to Reincorporate in the United States as Mirati Therapeutics, Inc. and List on the NASDAQ  
5/9/2013 9:56:27 AM

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Montreal, Canada, May 9, 2013 – MethylGene Inc. (“MethylGene”)(TSX:MYG) today announced that its Board of Directors (the “Board”), after careful analysis, consideration and advice from its legal, tax and accounting advisors, has unanimously approved a proposal to change MethylGene’s jurisdiction of incorporation from the federal jurisdiction of Canada to the State of Delaware in the United States of America by way of a court-approved plan of arrangement (the “Arrangement”).

Under the Arrangement, MethylGene will create a holding corporation, Mirati Therapeutics, Inc. (“Mirati”), incorporated in the State of Delaware, and Mirati will become the ultimate parent corporation of MethylGene and its subsidiaries. Concurrently with the Arrangement, Mirati is making an application to list its shares of common stock (“Mirati Shares”) on the NASDAQ Capital Market (“NASDAQ”), which we anticipate will result in the Mirati Shares being listed on both NASDAQ and the Toronto Stock Exchange (“TSX”) for a period of time. In connection with the NASDAQ listing, we will file with the Securities and Exchange Commission in the United States a registration statement on Form 10 for the purpose of registering the Mirati Shares under Section 12(g) of the Securities Exchange Act of 1934, as amended.

The Arrangement is subject to the approval of the Ontario Superior Court of Justice (the “Court”) and satisfaction or waiver of the conditions to closing set out in the arrangement agreement between the Corporation and Mirati dated May 8, 2013 (the “Arrangement Agreement”). In order to proceed and in addition to approval by the Court, a special resolution approving the Arrangement (the “Arrangement Resolution”) must be approved at the Meeting (as defined herein) by two-thirds of the votes cast by the shareholders of MethylGene (“Shareholders”), present in person or represented by proxy.

The annual and special meeting of Shareholders (the “Meeting”) to approve, among other things, the Arrangement Resolution, will be held on June 25, 2013 at 10:00 a.m. Toronto time (EDT), in the Grand Boardroom of the offices of Stikeman Elliott LLP at 1155 René-Lévesque Blvd. West, 40th Floor, Montréal, Québec. Shareholders of record as of the close of business May 16, 2013, will be entitled to receive notice of and vote at the Meeting.

The Board and management of MethylGene believe that the proposed Arrangement is in the best interests of MethylGene and, accordingly, recommend that Shareholders vote FOR the Arrangement Resolution. The Board determined that the Arrangement is in the best interests of MethylGene primarily due to the belief and rationale that the Arrangement should:

• improve Mirati’s ability to attract financing in the larger U.S. capital markets from a greater number of U.S. investors with investment interest in the biopharmaceutical industry, which has been where the majority of our investors in recent financings have come from;

• enhance the marketability of our capital stock by raising our profile in the United States, which is where over 90% of our Shareholders reside;

• ultimately improve the trading liquidity of the Mirati Shares compared to the current trading of the common shares of MethylGene (the “Common Shares”) on the TSX, through the combination of the additional listing on the NASDAQ, potentially lower Shareholder transaction costs and increased interest from institutional investors;

• eliminate potentially adverse “passive foreign investment company” tax issues for certain Shareholders who are U.S. citizens or resident in the United States; and

• provide greater opportunity to attract and retain key personnel.

The Board chose the State of Delaware because Delaware has a modern and flexible corporate code, well-developed corporate law and a court system with considerable expertise in dealing with corporate issues. In connection with the Arrangement, we intend to locate our corporate headquarters in the San Diego, California area, a major biotechnology center.

Upon completion of the Arrangement, it is anticipated that each Shareholder will receive one Mirati Share for every 50 Common Shares held, which will have the effect of a 1 for 50 reverse split of our Common Shares. Subject to adjustment for fractional shares and dissent rights, the Arrangement should have no material effect on the relative ownership and voting interests of Shareholders. In addition, all outstanding options and common share purchase warrants of MethylGene will become exercisable for Mirati Shares and their terms will be proportionately adjusted to reflect the 1 for 50 effective reverse split.

A management proxy circular (the “Circular”) in connection with the solicitation of proxies for the Meeting is expected to be mailed to Shareholders on approximately May 24, 2013, and will contain further details with respect to the Arrangement and proposed NASDAQ listing. The foregoing description of the Arrangement does not purport to be complete and is qualified in its entirety by reference to the Circular and the copy of the Arrangement Agreement, which will be available at www.sedar.com. MethylGene cautions Shareholders and others considering trading in securities of MethylGene that the Arrangement is subject to certain material conditions, some of which are beyond MethylGene’s control, including TSX, Shareholder and Court approval, and there can be no assurance that the Arrangement and the transactions contemplated therein, or any other transaction, will be completed. The transaction is expected to be completed in early July 2013.

About MethylGene

MethylGene is a publicly-traded biopharmaceutical company engaged in the development and commercialization of novel therapeutics for the treatment of cancer. Our compounds result from internal chemistry efforts targeting the active sites of enzymes that are key drivers of tumor growth. Our clinical development programs are focussed on treating patients with tumor types that are selected for high levels of expression of these targets in order to most effectively address unmet needs in oncology. Our lead program in clinical development is MGCD265, a multi-targeted small molecule kinase inhibitor for treatment of oncology patients with solid tumors. We are also evaluating development opportunities for pipeline programs mocetinostat, a selective HDAC inhibitor and MGCD516, a kinase inhibitor with a distinct target profile.

Investor Relations Contact:

MethylGene, Inc.

Mark J. Gergen

Executive Vice President & COO

Phone: 858-546-2902

Tracey Rowlands, Ph.D.

Manager Business and Corporate Development

Phone: 514-337-3333 ext. 512

ir@methylgene.com

www.methylgene.com

Michael Wood

Managing Director

LifeSci Advisors

Phone: 646 597 6983

mwood@lifesciadvisors.com

www.lifesciadvisors.com

Notice to Investors

This news release is for informational purposes only and is not an offer to buy or the solicitation of an offer to sell any securities.

Forward Looking Statements

Certain statements contained in this news release, other than statements of fact that are independently verifiable at the date hereof, may constitute forward-looking information and forward-looking statements (collectively “forward-looking statements” within the meaning of applicable securities laws), including statements relating to the results and the potential benefits expected to be achieved from the completion of the transactions contemplated by the proposed Arrangement, including the increased marketability and improved liquidity of the Mirati Shares and the NASDAQ listing. Such statements, based as they are on the current expectations of management of MethylGene and upon what management believes to be reasonable assumptions based on information currently available to it, inherently involve numerous risks and uncertainties, known and unknown, many of which are beyond MethylGene’s control. Such statements can usually be identified by the use of words such as “may”, “would”, “believe”, “intend”, “plan”, “anticipate”, “estimate” and other similar terminology, or state that certain actions, events or results “may” or “would” be taken, occur or be achieved. Any such forward-looking statements are based on information currently available to us, and are based on assumptions and analyses made by us in light of our experience and our perception of historical trends, current conditions and expected future developments, as well as other factors that MethylGene believes are appropriate in the circumstances.

However, whether actual results and developments will conform with our expectations and predictions is subject to a number of risks, assumptions and uncertainties, many of which are beyond our control, and the effects of which can be difficult to predict, including, without limitation: risks, assumptions and uncertainties related to: the consummation of the Arrangement, including, Shareholder approval, Court approval, the satisfaction or waiver of the other conditions to complete the transactions contemplated by the Arrangement, and the termination of the Arrangement Agreement; the market value and trading price of the Common Shares; and other factors set out in this news release and in the Circular under the heading “Risk Factors”, such as specific assumptions such as whether: MethylGene will achieve, sustain or increase profitability and whether it will be able to fund its operations with existing capital and/or it will be able to raise additional capital to fund operations; MethylGene will be able to attract and retain key personnel; MethylGene will be able to acquire any necessary technology or businesses and effectively integrate such acquisitions; MethylGene will be successful in developing and clinically testing products under development; MethylGene will be successful in obtaining all necessary approval for commercialization of its products from regulatory authorities; the results of continuing and future safety and efficacy studies by industry and government agencies relating to MethylGene’s products will be favourable; MethylGene’s products will not be adversely impacted by competitive products and pricing; raw materials and finished products necessary for MethylGene’s products will continue to be available; MethylGene will be able to maintain and enforce the protection afforded by any patents or other intellectual property rights; MethylGene’s products will be successfully licensed to third parties to market and distribute such products on favourable terms; MethylGene’s key strategic alliances, out licensing and partnering arrangements, now and in the future, will remain in place and in force; the general regulatory environment will not change in a manner adverse to the business of MethylGene and MethylGene will not become subject to any material legal proceedings.

In evaluating any forward-looking statements in this news release, MethylGene cautions readers not to place undue reliance on any forward-looking statements. Readers should specifically consider the various factors which could cause actual events or results to differ materially from those indicated by our forward-looking statements. Unless otherwise required by applicable securities laws, MethylGene does not intend, nor does it undertake any obligation, to update or revise any forward-looking statements contained in this news release to reflect subsequent information, events, results or circumstances or otherwise.



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