Novel Role of BRCA1 in Regulating the Survival of Skin Stem Cells Identified, Université Libre de Bruxelles Study
12/28/2012 7:25:14 AM
Researchers have uncovered a novel role of BRCA1 in regulating the survival of skin stem cells. Our DNA, which stores our genetic information, is constantly submitted to damage. If not properly repaired, DNA damage can lead to cell death, which may in turn lead to tissue exhaustion and aging, or induce mutations resulting in uncontrolled cell proliferation and cancer. Brca1 is a key gene that mediates DNA repair. Mutations in Brca1 lead to familial and sporadic breast and ovarian cancer in humans.