Laurantis Pharma Oy Issued Patent for Cis-UCA as a Treatment for Bladder Cancer  
10/9/2012 9:53:10 AM

TURKU, FINLAND--(Marketwire - October 09, 2012) -

The United States Patent and Trademark Office has allowed a patent application by Laurantis Pharma Oy (Laurantis) for the use of cis-urocanic acid (cis-UCA), an endogenous small-molecule component of human and animal skin with known anti-inflammatory and anti-cancer activity, for the treatment of bladder cancer.

In pre-clinical studies, cis-UCA was found to enhance several cellular processes known to expedite cell death in bladder cancer cells and to retard tumor invasion in the bladder. Laurantis researchers have moved the product into its first human clinical trial, which is currently recruiting patients in Finland. More information is available at

Laurantis currently has three proprietary cis-UCA based products in clinical development. The Company's lead product, cis-UCA emulsion cream for the treatment of atopic dermatitis, is currently in the final stages of phase 2 clinical development. Previously, the Company announced completion of a successful phase 1 clinical study with its cis-UCA eye drops. For bladder cancer, the product is delivered in a sterile, intravesical solution.

About Cis-UCA Technology
Laurantis Pharma's anti-inflammatory and anti-cancer products are based on the use of cis-UCA to modulate intracellular pH in the target cells. cis-UCA, an endogenous amino acid derivative, is a locally acting anti-inflammatory and anti-cancer agent that modulates the cytosolic pH under mildly acidic extracellular conditions. By acting as a proton transporter, it increases the proton concentration (i.e., decreases the pH) inside the cells. This protodynamic modulation of intracellular pH is a potent mechanism to alter cellular behavior, with important implications for inflammatory conditions and cancer.

Cis-UCA targets two major biochemical events that are critical to inflammation: blocking the production of reactive oxygen radicals and inhibiting the release of proinflammatory cytokines.