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Aerpio Initiates Phase 1b/2a Trial of AKB-9778 in Diabetic Macular Edema  
9/19/2012 10:06:25 AM

CINCINNATI--(BUSINESS WIRE)--Aerpio Therapeutics, a clinical-stage biopharmaceutical company developing innovative therapies for vascular diseases by targeting the Tie2 pathway, today announced that it has dosed the first patient in a Phase 1b/2a trial of AKB-9778 for the treatment of diabetic macular edema (DME). AKB-9778 is a first-in-class human protein tyrosine phosphatase beta (HPTP├č) inhibitor that works to activate Tie2, a receptor on vascular endothelial cells which promotes vascular stability, preventing abnormal blood vessel growth and vascular leak.
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