How Does Body Temperature Reset the Biological Clock? University of Geneva Study  
8/24/2012 6:59:54 AM

Numerous processes in our body fluctuate in a regular pattern during the day. These circadian (or daily) variations can be driven by local oscillators present within our cells or by systemic signals controlled by the master pacemaker, located in the brain. Ueli Schibler, profes- sor at the University of Geneva (UNIGE), Switzerland, unveils a mo- lecular mechanism by which body temperature rhythms influence the expression of 'clock genes' and synchronize local oscillators. This study, made in collaboration with a team at the Ecole polytechnique fe´de´rale of Lausanne (EPFL), also demonstrates how the production of DBP, a protein involved in detoxification and drug metabolism, is modulated by daily variations of temperature.