GHENT, BELGIUM--(Marketwire - April 04, 2012) - Ablynx (Euronext Brussels: ABLX) today noted
a paper on a novel tetrameric Nanobody(®) agonist (TAS266)
Receptor 5 (DR5), a key receptor target on cancer cells across a
tumour types, was presented at the American Association for Cancer
Annual Meeting in Chicago, USA, on 3 April 2012 by Novartis. The
TAS266 to efficiently 'cross-link' DR5 receptor targets, apparently
achievable with conventional monoclonal antibodies, results in the
death of cancer cells.
The paper was presented by Dr Heather Huet from Novartis and the
included three scientists from Ablynx.
The abstract summarizes the results of the pre-clinical in vitro and in
studies of a tetravalent anti-DR5 Nanobody in an oncology setting.
shown to elicit sustained tumour regressions in multiple tumour
models, including a patient-derived primary pancreatic tumour model
insensitive to a conventional anti-DR5 agonist antibody. Also, compared to
of the other therapeutic agonists against DR5 that have been developed and
have been clinically evaluated, TAS266 proved to be up to 1000-fold more
in tumour cell death assays.
In view of this, the authors of the abstract conclude that "TAS266
potential for superior clinical activity in settings insensitive to
conventional therapeutic approaches to DR5."
The abstract further states that "first-in-man trials for TAS266 are
begin in 2012."
Link to the presentation abstract: "TAS266, a novel tetrameric Nanobody
targeting death receptor 5 (DR5), elicits superior anti-tumour efficacy
conventional DR5-targeted approaches."
Commenting on today's announcement, Dr Edwin Moses, Chairman and CEO of
"Being present on cancer cells across a broad range of tumour types,
been the target of numerous conventional antibody approaches, but none
apparently been successful so far, possibly because of the need for
'cross-linking' to achieve the required activity. The ability to
tetravalent Nanobodies appears to allow more efficient 'cross-linking'
tumour micro-environment) and so potentially opens up a new pathway
treatment of certain cancers."
Ablynx is a biopharmaceutical company engaged in the discovery and
of Nanobodies(®), a novel class of therapeutic proteins based on
antibody fragments, for a range of serious and life-threatening human
including inflammation, haematology, oncology and pulmonary disease.
Company has over 25 programmes in the pipeline and seven Nanobodies at
development stage. Ablynx has ongoing research collaborations and
partnerships with major pharmaceutical companies, including
Ingelheim, Merck Serono and Novartis. The Company is headquartered in
Belgium. More information can be found on www.ablynx.com.
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Source: Ablynx via Thomson Reuters ONE