RIKEN: Signaling Pathway Reveals Mechanism for B Cell Differentiation in Immune Response  
4/22/2011 11:01:46 AM

Tokyo, Apr 22, 2011 (JCN Newswire) - An article in Science Signaling by researchers at the RIKEN Research Center for Allergy and Immunology (RCAI) has clarified for the first time the mechanism governing differentiation of B cells into antibody-producing plasma cells. The finding establishes a role for the extracellular signal-regulated kinase (ERK) signaling pathway in B cell differentiation, a key step toward the development of B cell-targeted drugs for treatment of autoimmune diseases and allergies.