This new patent (US 7,780,994) entitled "Composite biomaterials comprising calcium phosphate materials, collagen and glycosaminoglycans" describes and claims the composition of and methods to produce a composite material comprising a triple co- precipitate of collagen, one or more glycosaminoglycans (GAG) and calcium phosphate. This patent forms the core protection of our ChondroMimetic product family.

The patent application was filed in the name of Cambridge Enterprise and exclusively licensed to TiGenix Ltd. (the former Orthomimetics Ltd). The patent was already granted in the United Kingdom, Singapore and China. Additional patent applications are pending in other jurisdictions around the world.

“I’m extremely pleased with the issuance of this important US patent on the eve of the launch of ChondroMimetic. We expect further geographical expansion of ChondroMimetic’s intellectual property protection in the near future.” says Andrew Lynn, founder of Orthomimetics and co-inventor on the patent, now Chief Business Officer at TiGenix.

For more information, please contact:

Gil Beyen Kris Motmans Chief Executive Officer, TiGenix Corporate Development and Communication

T: +32 16 39 60 60 investor@tigenix.com

About TiGenix

Based in Leuven, Belgium, TiGenix NV (NYSE Euronext Brussels: TIG) is a public biomedical company that focuses on ‘Regenerating Motion’. The company is exploiting the power of Regenerative Medicine to develop durable treatments, validated through controlled clinical trials, for damaged and diseased skeletal tissues. TiGenix now has two products approved for marketing and sales in Europe:

ChondroCelect®, the company’s lead product for cartilage regeneration in the knee, is the first cell- based product that successfully completed the entire development track from research, over clinical development to central European registration as a medicinal product. ChondroCelect consists of characterized cultured chondrocytes derived from the patient’s own cartilage and is used for autologous chondrocyte implantation (ACI), a surgical procedure to treat cartilage defects. ChondroCelect received European Marketing Authorization as the first Advanced Therapy Medicinal Product.

ChondroMimetic™ is an off-the-shelf, collagen based implant for the treatment of small osteochondral (cartilage and underlying bone) defects. ChondroMimetic received CE-mark approval for the treatment of small chondral and subchondral lesions. It will be marketed as a procedure pack with the collagen implant preloaded in an accurate, easy to use delivery device.

The company exploits a proprietary (stem) cell and biomaterials platform, which will continue to generate candidate products that address specific musculoskeletal problems.

With a fully operational sales team in place, TiGenix is ready for commercial expansion and reinforcement of its leading position in Europe in the regenerative medicine field.

Forward-looking information This document contains forward-looking statements and estimates with respect to the anticipated future performance of TiGenix and the market in which it operates. Certain of these statements, forecasts and estimates can be recognized by the use of words such as, without limitation, “believes”, “anticipates”, “expects”, “intends”, “plans”, “seeks”, “estimates”, “may”, “will” and “continue” and similar expressions. They include all matters that are not historical facts. Such statements, forecasts and estimates are based on various assumptions and assessments of known and unknown risks, uncertainties and other factors, which were deemed reasonable when made but may or may not prove to be correct. Actual events are difficult to predict and may depend upon factors that are beyond the Company's control. Therefore, actual results, the financial condition, performance or achievements of TiGenix, or industry results, may turn out to be materially different from any future results, performance or achievements expressed or implied by such statements, forecasts and estimates. Given these uncertainties, no representations are made as to the accuracy or fairness of such forward-looking statements, forecasts and estimates. Furthermore, forward-looking statements, forecasts and estimates only speak as of the date of the publication of this document. TiGenix disclaims any obligation to update any such forward-looking statement, forecast or estimates to reflect any change in the Company’s expectations with regard thereto, or any change in events, conditions or circumstances on which any such statement, forecast or estimate is based, except to the extent required by Belgian law.

TiGenix NV • Romeinse straat 12 bus 2, 3001 Leuven, Belgium • 0471.340.123 RPR Leuven • tel +32 (16) 39 60 60 2/2