One Gene Lost = One Limb Regained? The Wistar Institute Scientists Demonstrate Mammalian Regeneration Through a Single Gene Deletion  
3/16/2010 7:48:23 AM

The Wistar Institute -- PHILADELPHIA – (March 15, 2010) – A quest that began over a decade ago with a chance observation has reached a milestone: the identification of a gene that may regulate regeneration in mammals. The absence of this single gene, called p21, confers a healing potential in mice long thought to have been lost through evolution and reserved for creatures like flatworms, sponges, and some species of salamander. In a report published today in the Proceedings of the National Academy of Sciences, researchers from The Wistar Institute demonstrate that mice that lack the p21 gene gain the ability to regenerate lost or damaged tissue.