Emerald BioStructures (Formerly deCODE biostructures) Publication in Nature Biotechnology Details Discovery of Allosteric Small Molecule Modulators of PDE4 with Reduced Side Effects  
12/28/2009 8:39:53 AM

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BAINBRIDGE ISLAND, Wash.--(BUSINESS WIRE)--Emerald BioStructures (formerly deCODE biostructures) announced today a publication in the December 27, 2009 advance online issue of Nature Biotechnology, detailing the application of structure-based drug design (SBDD) to engineer new allosteric small molecule modulators of the enzyme phosphodiesterase-4 (PDE4), with reduced side effects. According to the paper, the researchers established the structural basis of PDE4 regulation through crystal structures of the PDE4 regulatory domain in contact with small molecules.