Norak Biosciences, Inc. And SCYNEXIS, Inc. Announce Chemistry Collaboration 
10/19/2005 5:10:52 PM

RESEARCH TRIANGLE PARK, N.C., April 13 /PRNewswire/ -- Norak Biosciences, Inc. and SCYNEXIS, Inc. announced today that they have entered into a research collaboration to discover and develop novel pharmaceutical compounds. Under the agreement, Norak has transferred to SCYNEXIS certain active compounds and chemical structures from Norak's proprietary Transfluor(R) screening exercise of its chemical libraries against its novel desensitization targets. These will add to Norak's internal drug discovery pipeline.

The collaboration provides access by Norak to a SCYNEXIS research unit which includes MEDCHEM-FACTORY(TM) technology, HEOS(R) Hit Explorer Operating System software and medicinal chemistry expertise. This access will accelerate the identification of new leads for Norak's drug targets by producing large, focused, high-purity compound libraries and then utilizing rapid lead optimization to identify clinical candidates.

Specific financial terms were not disclosed. However, Norak will receive exclusive worldwide rights to products developed through the collaboration in exchange for technology access fees and other compensation for SCYNEXIS technologies and services.

"We are pleased to enter into this chemistry collaboration with such an exceptional medicinal chemistry company," commented Dr. Roger D. Blevins, Norak's president and CEO. "SCYNEXIS' proprietary compound library purification, analytical tools and strong medicinal chemistry expertise will rapidly advance our discoveries."

"SCYNEXIS is pleased to collaborate with NORAK in the discovery and development of new drugs. This collaboration allows our companies to match complementary innovative technologies, which have been validated by transactions with key pharmaceutical industry organizations, in a research unit arrangement that provides for mutual success," said Dr. Yves J. Ribeill, President & CEO of SCYNEXIS.

Norak's Transfluor technology is a patented, universal GPCR drug discovery technology designed to be the most accurate method for discovering ligands for GPCR targets, whether known or orphan. Transfluor was exclusively licensed in 1999 by Norak from technology developed at Duke University Medical Center and represents the combined research into GPCR signaling pathways over several decades by Norak's scientific founders, Drs. Marc Caron, Robert Lefkowitz, and Larry Barak.

Norak Biosciences, Inc., headquartered in Research Triangle Park, NC, is a private biotechnology company. Norak is utilizing its proprietary Transfluor technology to become a worldwide leader in the discovery and development of drugs that regulate G protein-coupled receptors. For more information about Norak Biosciences, Inc., please visit the Company's website at .

SCYNEXIS is a medicinal chemistry-focused drug discovery and development company headquartered in Research Triangle Park, North Carolina with European operations, SCYNEXIS Europe Ltd., located near Cambridge, England. By combining its chemists' expertise with its proprietary MEDCHEM-FACTORY(TM) technology and Hit Explorer Operating System (HEOS(R)), SCYNEXIS provides improved speed and productivity in the chemical validation of drug targets. SCYNEXIS also offers novel hit generation compounds, hit explosion and lead optimization services as well as process optimization, purification and analysis of compound libraries, in vitro and in vivo ADMET, the production of clinical samples in its GMP facility and radiochemistry synthesis services. For more information, please visit .

Media Contacts: For NORAK: Terry Willard (919) 248-8000 x8804 For SCYNEXIS in the US: Rick Rountree (919) 786-0872 For SCYNEXIS in Europe: Andy Matthews, O2PR +44 (0) 1223 309500 Business Development Contacts: For NORAK: Terry Willard (919) 248-8000 x8804 For SCYNEXIS in the US: Terry Marquardt (919) 544-8600 For SCYNEXIS in Europe: Simon Saxby +44 (0) 1277 367001

Norak Biosciences, Inc.; SCYNEXIS, Inc.

CONTACT: Media, Terry Willard, +1-919-248-8000, Ext. 8804,, for Norak; or Rick Rountree, +1-919-786-0872,, for SCYNEXIS in the US; or Andy Matthews of O2PR,+44-0-1223-309500, or, for SCYNEXIS in Europe; orBusiness Development Contacts, Terry Willard, +1-919-248-8000, Ext. 8804,, for Norak; or Terry Marquardt, +1-919-544-8600,, for SCYNEXIS in the US; or Simon Saxby,+44-0-1277-367001, or, for SCYNEXIS in Europe