Manchester, UK, 22 October 2008 - F2G Limited, the Manchester UK based antifungal drug
discovery and development company, today announced that abstracts related to their novel
antifungal agent have been selected for oral and poster presentations at the upcoming 48th
Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) at the Walter E.
Washington Conference Centre, Washington DC, 25th – 28th October 2008.
F2G will present six posters in ‘Poster session 105: New Antifungal Agents’ and the Company’s
CSO, Dr Lloyd Payne, has also been allocated a speaking slot during the Saturday morning
Poster Summary Session 3 entitled ‘All New Antimicrobial Agents’. Shane Kelly, Chief
Executive of F2G, commented “We are delighted that the ICAAC Organising Committee has
accepted our poster presentations and invited us to speak at the conference. This invitation
represents an important validation of our science and is a significant achievement for the
company. 2008 has been a milestone year as our candidate drug, which originates from F2G’s
in-house screening program, has entered full preclinical development.”
F2G’s candidate drug represents the first generation of a novel class of systemic antifungal
agent and offers the potential for a major advance in antifungal therapy. The mechanism of
action, identified by scientists at F2G, involves the selective inhibition of a fungal enzyme and is
completely distinct from any other class of marketed antifungal agent. The compound displays
highly potent activity against a wide range of clinically significant moulds including the common
pathogen Aspergillus fumigatus which is known to cause Invasive Aspergillosis, a serious,
debilitating disease associated with high mortality rates despite current therapy options.
The planned poster presentations at ICAAC 2008 highlight the potent in vitro antifungal activity
of the new compound against a wide range of clinically significant fungi including Aspergilli sp.
The pharmacokinetics profile of the agent and its ADMET properties are described as well as
data pertaining to the excellent efficacy of the novel agent in highly validated models of
About F2G Ltd:
Based in Manchester, UK, F2G Ltd is dedicated to the discovery and development of new and
clinically superior drug classes to treat life-threatening systemic fungal infections in at-risk
patient populations. The antifungal market is currently estimated at over five and a half billion
dollars annually and is growing steadily year on year. Market growth is expected to increase with
the emergence of new clinical indications in allergies and asthma.
F2G recently completed a ?6.3million equity financing round with an international syndicate of
investors to fund the further development of the company’s lead compound and back-up
programs. The company has impressive internal capabilities, employing a core team of
scientists with a unique understanding of the antifungal arena, supported by an experienced
management team. F2G operates a flexible business model, building value through the
development of a balanced portfolio of antifungal assets across multiple validated TPPs.