TORONTO, Nov. 18, 2016 /PRNewswire/ -- Current gene data reported by Replikins LLC and Ltd. today indicates that Zika is moving into an endemic pattern globally, i.e., while there is slight reduction in Replikin Counts globally, the Count in Brazil has risen again suggesting a buildup for the coming summer season in that country.
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Two of the time-course patterns of gene mutation and molecular evolution observed by gene Replikin Counts, which correlate with clinical courses are:
1.) "Gradual" gene mutations (at p<0.001) over a period greater than two years in advance of the clinical outbreak, followed by gradual cessation of both the gene change and of the clinical outbreak, subsequently followed by annual endemic recurrences (e.g. HINI influenza pandemic of 2009-10); and
2.) "Rapid" gene mutations (at p<0.001) within 1-2 years in advance of the clinical outbreak with high mortality, followed by rapid cessation of gene change within the year of the outbreak, followed promptly by rapid cessation of the outbreak, and no recurrence within two years (e.g. Ebola 2014 and SARS 2003). From the current genomic data, it appears that Zika is taking an endemic course.
Samuel Bogoch, MD, PhD
Nature Precedings doi:10.1038/npre.2011.6279.1;doi: 10.1038/npre .2012.7144.1. Marked Increase in Ebola Gene Replikin Count in 2012 & 2013 Predicted Current Ebola Outbreak; Does Recent Sharp Drop in Replikin Count Signal Early End for the Current Ebola Outbreak? Reuters, October 4, 2014
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SOURCE Replikins Ltd.