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Merck KGaA (MKGAF.PK), Darmstadt, Germany, Presents Phase II Data On The Safety And Efficacy Of Atacicept At The 2016 ACR/ARHP Annual Meeting



11/2/2016 8:21:32 AM

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DARMSTADT, Germany, November 2, 2016 /PRNewswire/ --

•Results from phase II investigations of atacicept in systemic lupus erythematosus (Abstract Numbers: 12L and 764)

Merck KGaA, Darmstadt, Germany, a leading science and technology company, today announced that clinical data on atacicept, an investigational drug for systemic lupus erythematosus, are scheduled to be presented in poster sessions at the 2016 American College of Rheumatology/Association of Rheumatology Health Professionals (ACR/ARHP) Annual Meeting taking place from November 11-16, 2016, in Washington, DC, U.S.

"There is a significant unmet medical need in systemic lupus erythematosus, with limited treatment options currently available for this debilitating disease," said Luciano Rossetti, Head of Global Research & Development for the biopharma business of Merck KGaA, Darmstadt, Germany. "The safety and efficacy data that will be presented at ACR/ARHP indicate that atacicept may play an important role as a potential new therapeutic option for patients with lupus. Our goal is to continue to advance innovation across our immunology pipeline that could make a meaningful difference for people living with lupus and other autoimmune diseases."

Notes to Editors

Accepted Merck KGaA, Darmstadt, Germany-supported abstracts, including a late-breaking poster presentation, are listed below.

For more information about the data to be presented, please review the ACR/ARHP website. Also, visit Merck KGaA, Darmstadt, Germany's booth at this year's Annual Meeting to learn more about the company's commitment to advancing innovation in lupus and other immunological diseases.

About Atacicept

Atacicept is a potential treatment for systemic lupus erythematosus (SLE). Atacicept, a recombinant fusion protein, contains the soluble TACI receptor that binds to the cytokines BLyS and APRIL. These cytokines are members of the tumor necrosis factor family that promote B-cell survival and autoantibody production associated with certain autoimmune diseases such as SLE. Atacicept has been shown in animal models to affect several stages of B-cell development and may inhibit the survival of cells responsible for making antibodies. Merck KGaA, Darmstadt, Germany, acquired exclusive worldwide development and commercialization rights for atacicept, including in North America, from Zymogenetics in 2008. Atacicept is currently under clinical investigation and not approved for any use in the United States, Canada and Europe.

About Systemic Lupus Erythematosus (SLE)

Lupus is a chronic inflammatory disease, where the immune system attacks the body's own tissues and organs. Systemic lupus erythematosus (SLE) is the most common form of lupus and can result in swollen, painful joints, skin rash, extreme fatigue and kidney damage. Estimates vary widely, but SLE may affect as many 300,000 patients in the U.S. alone. Women and individuals with African, Asian, and Hispanic heritage are affected disproportionately by SLE.

About EMD Serono, Inc.

EMD Serono is the biopharma business of Merck KGaA, Darmstadt, Germany, in the U.S. and Canada - a leading science and technology company - focused exclusively on specialty care. For more than 40 years, the business has integrated cutting-edge science, innovative products and industry-leading patient support and access programs. EMD Serono has deep expertise in neurology, fertility and endocrinology, as well as a robust pipeline of potential therapies in oncology, immuno-oncology and immunology as R&D focus areas. Today, the business has more than 1,100 employees around the country with commercial, clinical and research operations based in the company's home state of Massachusetts.

http://www.emdserono.com

All Merck KGaA, Darmstadt, Germany, press releases are distributed by e-mail at the same time they become available on the Merck Website. Please go to http://www.merckgroup.com/subscribe to register online, change your selection or discontinue this service.

About Merck KGaA, Darmstadt, Germany

Merck KGaA, Darmstadt, Germany, is a leading science and technology company in healthcare, life science and performance materials. Around 50,000 employees work to further develop technologies that improve and enhance life - from biopharmaceutical therapies to treat cancer or multiple sclerosis, cutting-edge systems for scientific research and production, to liquid crystals for smartphones and LCD televisions. In 2015, Merck KGaA, Darmstadt, Germany, generated sales of € 12.8 billion in 66 countries.

Founded in 1668, Merck KGaA, Darmstadt, Germany, is the world's oldest pharmaceutical and chemical company. The founding family remains the majority owner of the publicly listed corporate group. Merck KGaA, Darmstadt, Germany, holds the global rights to the Merck KGaA, Darmstadt, Germany, name and brand. The only exceptions are the United States and Canada, where the company operates as EMD Serono, MilliporeSigma and EMD Performance Materials.

(Logo: http://photos.prnewswire.com/prnh/20160629/384917LOGO )

SOURCE Merck KGaA, Darmstadt, Germany

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