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Integrated BioTherapeutics Announces Licensing Agreement With Emergent BioSolutions (EBS) For Development Of Equine Immunoglobulin Therapeutics For Filovirus Infections

11/15/2016 8:11:49 AM

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ROCKVILLE, Md., Nov. 15, 2016 /PRNewswire/ -- Integrated BioTherapeutics (IBT) announced today that it has entered into an exclusive worldwide license agreement with Emergent BioSolutions Inc. (NYSE: EBS) whereby Emergent will gain exclusive rights to use IBT's proprietary vaccine antigens and know-how in a joint research, development, and manufacturing collaboration focused on an equine-based hyperimmunoglobulin for the treatment of hemorrhagic fever caused by Filoviruses.  Financial terms of the agreement are not disclosed. 

Filoviruses, including Ebola, Sudan, Bundibugyo, and Marburg viruses, cause a highly fatal disease in humans.  The 2014-2015 Western Africa Ebola virus disease (EVD) outbreak caused approximately 29,000 infections and more than 11,000 deaths.  While significant progress has been made towards vaccines and therapeutics for the Zaire strain of Ebola virus, the strain that caused the 2014 outbreak, the development of therapeutics against other filoviruses is lagging.  The goal of this multivalent equine product is to protect against multiple filovirus strains.

"Effective post-exposure therapeutics against filoviruses is critically important for control of future outbreaks of these deadly infections," said Dr. M. Javad Aman, IBT's President and Chief Scientific Officer. "It is impossible to predict which filovirus strain will cause the next outbreak and therefore, our focus should be to develop therapeutics that can provide broad protection." 

The development of this critically important hyperimmune product candidate is being directed under the auspices of a collaboration between IBT, Emergent, Auburn University, Public Health Agency of Canada, and US Army Medical Research Institute of Infectious Diseases (USAMRIID).  Emergent, supported by IBT and their network of collaborators, intend to develop this product candidate towards approval by the U.S. Food and Drug Administration for treatment of filovirus hemorrhagic fever.  Once approved, the product may be produced for inclusion in the Strategic National Stockpile for emergency use or in response to possible future outbreaks. 

About Equine Immunoglobulins

Equine immunoglobulins are produced by hyperimmunization of horses with specific antigen preparations that can induce protective antibody responses.  Hyperimmune antibody preparations from horse serum or plasma have been used over the past century for the treatment of a variety of infectious diseases, intoxication, or envenomation such as snake envenomation, spider bites, botulism, rabies, diphtheria, and tetanus.  One equine immunoglobulin product, Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G) (BAT®), developed by Emergent, is currently included in the U.S. Strategic National Stockpile. 

About Integrated Biotherapeutics (IBT)

IBT is a biotechnology company focused on the discovery of novel vaccines and therapeutics for emerging infectious diseases with a pipeline that includes promising product candidates for bacterial and viral infections including unique pan-filovirus candidates, vaccines and a variety of other product candidates for emerging viruses.  IBT has a state of the art laboratory facility in Rockville, MD. For more information, visit IBT also operates a discovery service and reagent business (IBT Bioservices) focused on in vitro and in vivo testing of anti-infective vaccine and drug candidates. For more information, visit

Contact: Maggie Tihanyi, 1-240-778-6513,


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SOURCE Integrated BioTherapeutics

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