Bristol-Myers Squibb (BMY) Release: Interim Phase 1/2 Data Show Encouraging Clinical Benefit For Lirilumab In Combination With Opdivo (Nivolumab) In Patients With Advanced Platinum Refractory Squamous Cell Carcinoma Of The Head And Neck
11/14/2016 12:52:52 PM
PRINCETON, N.J., & MARSEILLE, France--(BUSINESS WIRE)--Bristol-Myers Squibb Company (NYSE:BMY) and Innate Pharma SA (Euronext Paris: FR0010331421 – IPH) today announced an interim efficacy analysis from a Phase 1/2 study of the combination of lirilumab and Opdivo (nivolumab) in the cohort of advanced platinum refractory squamous cell carcinoma of the head and neck (SCCHN), including exploratory biomarker analyses of patient response by level of PD-L1 expression. Among 29 evaluable patients with SCCHN, the objective response rate (ORR), a secondary endpoint measured by Response Evaluation Criteria In Solid Tumors (RECIST), was 24% (n=7). Seventeen percent (n=5) of these evaluable patients had deep responses, with reductions in tumor burden greater than 80%. Early signals of enhanced clinical benefit were observed in PD-L1 positive tumors, with an ORR of 41% (7/17) in patients with =1% PD-L1 expression.
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