VP, Immuno-Oncology Research - South San Francisco, CA | Biospace
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VP, Immuno-Oncology Research

Five Prime Therapeutics, Inc.

South San Francisco, CA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Areas of Expertise Desired:

Job Description

Five Prime Therapeutics, Inc. (NASDAQ: FPRX) is a biotechnology company focused on discovering and developing transformative protein-based medicines for patients with serious unmet medical needs.  The company has an emerging portfolio of innovative products for cancer and inflammation, and currently has 3 protein therapeutics in clinical testing covering 11 indications.  

  •      Cabiralizumab (FPA008) – a monoclonal antibody targeting CSF1R in various disease areas including immuno-oncology, solid tumors and inflammation    
  •      FPA144 – a monoclonal antibody targeting FGFR2b for selected gastric cancers    
  •      FP-1039 – An FGF ligand trap in Phase 1b for mesothelioma    

   FivePrime also focuses on developing companion diagnostic and biomarker strategies for the appropriate therapeutic settings. Five Prime’s discovery platforms can rapidly interrogate the entire extracellular proteome in medically relevant in vitro and in vivo models leading to novel targets and drug leads.  Our technology has been validated by our growing pipeline and through multiple partnerships with pharmaceutical companies including GlaxoSmithKline, UCB, and Bristol-Myers Squibb across a range of therapeutic indications.  FivePrime is committed to innovation and outstanding science, values that are reflected in our people and our products.  

   The Position:  

   Five Prime is seeking a Vice President of Immuno-Oncology research who will work closely with the Head of Research and the management team to provide scientific leadership and help progress breakthrough assets from discovery to the clinic.  Ideally, the candidate will have had significant experience and accomplishments in both academia and in the pharmaceutical/biotechnology industry and will be an expert in the areas of immunology, oncology, and biologics.  He/she must bring a strong entrepreneurial orientation along with highly developed leadership and team-building skills.  The ideal candidate will be a seasoned executive with an outstanding record of accomplishment in immune-oncology research and all aspects of drug discovery.  A thorough understanding of the requirements and processes needed in drug development, in particular biologics, from target identification to IND-enabling studies is essential.  The VP of Immuno-Oncology (IO) will be responsible for overseeing and growing the IO research organization into a highly competitive and innovative organization among its peers in the biotech and pharma industry.   


  •      Provide scientific vision and leadership to advance Five Prime’s platforms and future product portfolio. Deliver high quality lead candidates for clinical development.    
  •      Lead and grow the IO research organization to execute the discovery and development of new therapeutic drug candidates.    
  •      Provide strategic input for Research’s mid- and long-term goals.    
  •      Partnering with senior management and the company’s Executive Committee to help establish company’s strategic Discovery Research roadmap and to provide exemplary scientific input into company’s research and development programs.    
  •      Provide other members of the senior management team with continuous scientific input in the areas of business development, clinical development and commercialization, regulatory matters, manufacturing, funding processes and initiatives.    
  •      Very close collaboration and partnership with the Clinical and Development Sciences groups to drive pre-clinical and clinical strategic objectives and pipeline.    
  •      Active member of the Research Steering Committee (RSC).    
  •      Recruit, motivate, retain, and develop a world class, highly innovative immuno-oncology research organization.    
  •      Establish a culture that promotes creativity, open communication, collaboration, collegiality, and a high sense of urgency. Maintain the highest standards of scientific rigor.    
  •      Actively engage with Five Prime’s leaders and advisors. Build and maintain exceptional working relationships with them and with key opinion leaders and lead principal investigators as portfolio advances.    
  •      Maintain deep understanding of therapeutic areas of interest, including work by competitors and research developments in relevant technology and therapeutic areas through broad and active engagement and leadership in the scientific community.    
  •      Actively lead and support the establishment and execution of external alliances with industry partners, with relevant non-profit organizations, and with academic groups to enhance and expedite the development of the company’s discovery programs and platform.    
  •      Represent Five Prime’s technology and future portfolio both internally and externally to scientific, regulatory, and business communities, including key opinion leaders, academics, clinicians, non-profit groups, regulatory authorities, potential partners, and potential investors.    
  •      Participate in the creation of a robust and industry-leading intellectual property portfolio.    


   The successful candidate for the position of VP of Immuno-Oncology must have a demonstrated record of accomplishments in drug discovery and development within the life sciences industry. A successful track record of developing and delivering therapeutic candidates – “from bench to the clinic“– is essential. A minimum of 15 years industry experience in leading multidisciplinary teams and portfolios is required.  

   The ideal candidate will have had senior level scientific/technical responsibility with substantial experience in the successful discovery and development of biologic therapeutics in the areas of immunology and oncology.  

   This VP of Immuno-Oncology will have a thorough understanding of all the requirements and processes needed in drug development from target discovery to clinical development. He/she must bring a strong entrepreneurial orientation along with highly developed leadership and team building skills. A solid understanding of the industry’s complex regulatory requirements to develop therapeutics and an absolute commitment to competing at the highest ethical level are essential.  

   Key Requirements Include:  

  •      Expert scientific knowledge and experience in the areas of immunology and oncology is required. Knowledge of other therapeutic areas such as inflammation and auto-immunity is highly preferred.    
  •      Scientific excellence, to include at least 15 years of experience in research and development preferably in pharma and/or biotechnology companies    
  •      Strong functional leadership and prior management experience leading a team of senior Scientists within discovery organization    
  •      Significant familiarity with validation of drug targets and the exploratory drug development process. Proven biopharmaceutical industry experience developing and leading innovative therapeutic programs and advancing complex technologies.    
  •      Experience with various biologics platforms is ideal. This includes, but is not limited to canonical and engineered antibodies, bi-specific antibodies, engineered Fc-ECD fusion proteins, and other biologic scaffolds.    
  •      Strong publication record in peer reviewed journals across therapeutic areas and patent record.    
  •      Experience navigating intellectual property / patents.    
  •      Overall business understanding including experience in business development and licensing contracts.    
  •      Distinctive Leader:               
    •          Creative, collaborative, proactive and confident individual with proven leadership performance.        
    •          Strategic thinking, have a vision for defining the end-goal, be able to effectively communicate the goal, and ability to adapt the goals based on changed circumstances and business objectives.        
    •          A leader with a “success mindset” and confidence factor        
    •          Positive, self-confident leader, who uses critical thinking, constructive judgment and an analytical approach to strategy and decision-making.        
    •          Able to readily command the respect of and inspire a highly skilled IO research organization.        


  •      Ph.D. and Post-doctoral training in Immunology or closely related discipline is required    

   Please upload your cover letter & CV.