The Laboratory Animal Sciences Program (LASP) provides exceptional quality animal care and technical support services for animal research performed at the National Cancer Institute at the Frederick National Laboratory for Cancer Research. LASP executes this mission by providing a broad spectrum of state-of-the-art technologies and services that are focused on the design, generation, characterization and application of genetically engineered and biological animal models of human disease, which are aimed at the development of targeted diagnostics and therapies. LASP contributes to advancing human health, developing new treatments, and improving existing treatments for cancer and other diseases while ensuring safe and humane treatment of animals.
To accomplish this mission, the LASP is organized into numerous subgroups with varying and distinct functions. The Veterinary Pathologist in the Veterinary Pathology Section (VPS) of the larger Pathology and Histotechnology Laboratory (PHL) specializes in consult/design of animal necropsy protocols, phenotyping of genetically engineered mice (GEM), immunopathology, anatomic pathology, and toxicological pathology. This includes: assisting in animal study design, including generation of study-specific necropsy and trim protocols; providing histopathology and immunohistopathology diagnosis/evaluation, qualitative and quantitative analysis/scoring, summary reporting, and subsequent manuscript preparation; providing specimen classification/ selection for tissue microarrays, laser cutting (LC) and laser micro dissection (LCM); providing rapid quality diagnostic histopathology support in partnership with the LASP Animal Health and Animal Molecular Diagnostic Laboratories. The VPS works closely with the LASP Histotechnology Laboratory (HL) which offers complimentary support including non-human hematology and blood chemistry testing, complex necropsy, fixed and frozen tissue processing, microtomy, histological staining, enzyme stains, 600+ validated immunohistochemistry assays, custom ISH assay support, and custom nucleic acid isolation options for frozen/fixed animal and human tissue blocks, cores, and precut slides including yield and quality assessments. The PHL also supports a wide range of digital imaging options including photography and Aperio digital whole slide scanning (bright field and fluorescent).
JOB DESCRIPTION/BASIC FUNCTION
This job description will be used to identify candidates with skills and experience for multiple level of positions within Leidos Biomedical Research. Candidates who express an interest will be considered for current and future positions.
The Veterinary Pathologist works with Pathology and Histology Laboratory personnel to provide comprehensive pathology support for NCI investigators, which includes the following primary functions:
Consultative services for principal investigators on a wide variety of research activities with a major focus on studies of functional genomics and disease mechanisms utilizing genetic approaches and in particular transgenic and gene-targeted mouse models
Timely histopathology and immunohistopathology evaluation/diagnosis, related qualitative and quantitative IHC analysis/scoring, summary reporting, and subsequent manuscript preparation
Quality assurance and rapid diagnostic histopathology support for the LASP Animal Health and Animal Molecular Diagnostics Laboratories animal-health monitoring program
Develop and/or review standard operating procedures of the pathology program
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
Possession of a D.V.M. or V.M.D. degree or satisfactory completion of the foreign equivalency examination (passing grade) given by the AVMA. Diplomate of the American College of Veterinary Pathologists (DACVP)
Foreign degrees must be evaluated for U.S. equivalency
Minimum of two (2) years of relevant experience in the area of molecular and/or comparative pathology
Documented publications in peer-reviewed journals
Must be able to obtain and maintain a Security Clearance
Candidates with these desired skills will be given preferential consideration:
Experience in image analysis, immunohistochemistry (IHC), tissue micro arrays, genetically-engineered mice and comparative pathology
Project management experience in a research setting
Understanding of translational science/medicine including next-generation sequencing, gene expression profiling, in situ hybridization (ISH), and proteomics
Knowledge of current research trends
Excellent oral and written communication skills