Translational Research Laboratory Manager - Philadelphia, PA | Biospace
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Translational Research Laboratory Manager

Spark Therapeutics

Philadelphia, PA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Bachelors Degree
Areas of Expertise Desired:
Assay, Assay Development, Biology, Biotechnology, Cell Biology, Drug Discovery, Genetics, In Vivo, Laboratory, Manager, Pharmacology, PhD, Translational,

Job Description

Manage the day to day technical operation of the translational lab, inclusive of:  assay development, pharmacology & toxicology, and discovery research.
Champion all safety aspects in the Translational Laboratories.
Implement and manage an inventory system for biological reagents (plasmids, cells, vectors) and co-ordinate reception and shipment of reagents.
Train and assist technical staff in the performance of laboratory experiments ensuring work is completed according to project time lines.
Responsible for short and long term planning for all aspects of lab operations, maintaining focus on scientific goals of the pipe line programs.
Oversee and manage the day-to-day operations of our external vivarium vendor.
Ensuring adequate personnel, space, equipment, and facilities remain available.
Coordinate the work load in collaboration with other department leads.
Independently design, determine techniques and perform experiments on the bench.  
Mentor and develop staff. Train and assist technical staff in the performance of laboratory experiments.  Responsible for all safety aspects and best practices, and employee training.
Ensure departmental goals and objectives are met and aligned to the broader organizational goals and objectives.
Prioritize and plan projects and workloads, manage resources and personnel scheduling.
Coordinate and align centralized lab management efforts across assay development, pharmacology, toxicology and discovery research.  
Short and long term planning of lab operations
Oversee and manage the day-to-day operations of our external vivarium vendor
Implement and maintain Spark Translational inventory system
Supplier & Vendor Management and negotiations
Manage translational research samples and materials


Bachelor’s degree required; PhD in a relevant field preferred.
Minimum of 5-8 years of strategic and hands-on laboratory experience.
Previous management or supervisory experience strongly preferred.
Broad understanding of the technical and equipment needs in a lab as well as extensive hands-on experience with standard molecular and cell biology techniques such as DNA cloning, qPCR, ELISA, flow cytometry, cell culture, etc.
Experience with AAV vectors is a plus.
Strong organizational skills.
Excellent writing and verbal communication skills.
Demonstrated ability to effectively manage performance and talent.
Demonstrate independent problem solving skills of technical issues; develop solutions to a variety of moderate to complex problems; Discuss with supervisor and refer to policies/practices for guidance.
Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark.
Exercise judgment within defined procedures and practices to determine appropriate action.
Quality Assurance, Clinical Operations, Pharm/Tox, Discovery, Assay Validation, R&D Operations, Technical Operations, Regulatory Affairs