Staff Pathologist (NCI) - Frederick, MD | Biospace
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Staff Pathologist (NCI)

Leidos Biomedical Research, Inc.

Frederick, MD
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Areas of Expertise Desired:

Job Description

The Center for Advanced Preclinical Research (CAPR), founded in 2008 under the aegis of the NCI’s Center for Cancer Research (CCR), is a dedicated organization proficient in the use of modern murine cancer models for translational science and applied preclinical research. Its major mission is to develop, disseminate, and implement reproducible preclinical best practices validated for guiding clinical research toward improved cancer patient management. In order to have an impact on the development of efficacious therapies, preclinical research must utilize a diversity of cancer models that best incorporate the biology and genetics critical to a given therapeutic approach for each cancer type. CAPR partners with Leidos technology facilities and CCR cores to achieve abroad range of capabilities required for effective preclinical cancer research. CAPR collaborates extensively with intramural NCI and external academic groups, as well as with scientific foundations, research consortia, and a gamut of commercial organizations. CAPR has established robust reproducible operating procedures for numerous pathway-driven GEM cancer models, and maintains a portfolio of collaborative agreements, including support for CCR investigators, funded partnerships with pharma and biotech companies to evaluate lead and candidate therapies. CAPR experts also oversee development of a significant number of innovative GEM tools and cancer models for dissemination among the scientific and drug development communities.

The Veterinary Pathologist will:
Direct the Pathology section of the Center for Advanced Preclinical Research (CAPR). CAPR conducts preclinical research in mouse cancer models, including genetically engineered and patient-derived xenograft models, to evaluate disease development, therapeutic efficacy, and biomarkers
Is expected to work closely with Program leadership and scientific staff to design experimental strategies for numerous studies and thus have extensive expertise in mouse cancer histopathology and molecular pathology
Lead multiple activities related to his/her expertise, including timely histopathology and immunohistopathology evaluation/diagnosis, IHC analysis and scoring, the design and execution of animal necropsy protocols, characterization of disease and responses to therapy
Is responsible for directing pathology lab maintenance activities that include supervising histotechnologist, processing of specimen, and equipment maintenance (microscopes, digital slide scanners, automated bondmax immunostainer, tissue embedding station, microtomes and cryotome)
The Veterinary Pathologist is also responsible for providing guidance to CAPR senior staff and other scientists at the National Cancer Institute (NCI), preparing written reports for publications and formal reports to collaborators, and participating in assembling scientific presentations.


To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
Possession of Doctoral degree (e.g., DVM, D.Sc., M.D., or PhD.) from an accredited college or university according to the Council for Higher Education Accreditation (CHEA) appropriate to biomedical research.
Foreign degrees must be evaluated for U.S. equivalency.
Two (2) years of relevant experience in the areas of molecular and/or comparative pathology
Experience in pathology evaluation of genetically engineered mice
Ability to plan, conduct, and continuously improve a large, complex, integrated multidiscipline pathology support operation
Documented publications in peer-reviewed journals
Must be able to obtain and maintain a security clearance
Candidates with these desired skills will be given preferential consideration:
A combination of a DVM and PhD or MD degrees
Diplomate of the American College of Veterinary Pathologists (DACVP) certification
Deep understanding of the current experimental strategies and technologies in translational science/medicine including next-generation DNA and RNA sequencing, gene expression profiling, tissue micro arrays, immunohistochemistry (IHC), cytology, in situ hybridization (ISH), systems biology and multi-omics platforms
Significant understanding of human cancer pathologies
Demonstrated knowledge of current research trends in translational science, with the emphasis on cancer biology, and preclinical drug development
Image analysis and comparative clinical pathology expertise is a strong plus
Extensive organization skills and expertise in computer-based data management