Sr Scientist / Principal Scientist – Bioinformatics Immuno-Oncology - Gaithersburg, MD | Biospace
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Sr Scientist / Principal Scientist – Bioinformatics Immuno-Oncology

MedImmune, LLC

Gaithersburg, MD
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Areas of Expertise Desired:

Job Description

                                       Location:Gaithersburg, Maryland, United States
Job reference: R-002786

Posted date: Feb. 02, 2017


   If you’re inspired by the possibilities of science to change lives and you thrive when making brave decisions – join us.  

   MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.  As a Sr Scientist (grade 4) / Principal Scientist (grade 5) Bioinformatics Immuno-Oncology in Gaithersburg, MD, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.  

   We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.  

   MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.  

   Main Duties and Responsibilities  

   We are looking for an exceptional bioinformatics scientist with expertise in immuno-oncology research to apply state of the art genomics/genetics analytical approaches to help with understanding of disease mechanism, genetic variants, biological pathways, and predictive biomarkers with the ultimate goal of developing therapies.  You will have both scientific and technical skills in oncogenomics to identify cancer neoantigens that can be experimentally validated.  

   You will be responsible for leading the development of a robust analytical pipeline for neoantigen prediction, in addition to conducting correlative clinical studies and interpreting complex biological results for data generated from qRT-PCR, microarray and DNA/RNA sequencing projects.  


   Essential Requirements  

   Sr Scientist:  Minimum of 8 years relevant experience post degree  

   Principal Scientist:  Minimum of 10 years relevant experience post degree  

   For both roles:  

  •      PhD in biological sciences, computational biology, bioinformatics, or relevant field    
  •      Minimum of 5 years proficiency with R/Splus and at least one additional programming language    
  •      Experience analyzing biomarkers and developing scientific hypotheses based on disease pathogenesis and drug mechanism of action (MOA) in the areas of oncology    
  •      Experience working with cancer databases (e.g. TCGA, ICGC), conventional NGS tools, and MHC/peptide algorithms (e.g. NetMHCpan)    
  •      Experience presenting results at scientific conferences    
  •      Strong oral and written skills    
   Desirable Requirements  
  •      Ability to interact in a cross-functional environment    
  •      Capable of multitasking and working effectively with scientists from translational oncology and respiratory, inflammation and autoimmune (RIA)    
  •      Capable of working on multiple simultaneous projects    

   Next Steps – Apply today!  


   To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.  

   AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.