Zymeworks is a fast-growing, clinical-stage biotechnology company dedicated to the research, development and commercialization of best-in-class therapeutic bispecific antibodies and antibody drug conjugates for the treatment of cancer and autoimmune diseases. Zymeworks is proud to have active collaborations with Merck & Co., Inc., Eli Lilly and Co., Celgene Corporation and GSK, and is committed to making a meaningful difference in the lives of patients everywhere.
Zymeworks is seeking a creative and analytical immunologist with a proven track record of applying cutting edge cellular and biochemical methods to understand pathogenic human T cell responses. This position requires drug discovery project leadership abilities; ideal candidates will employ a hands-on approach to designing, managing, and conducting studies to support therapeutic lead candidate identification. This position will report to the Principal Scientist, Therapeutics Reseach and can be based in Seattle, WA or Vancouver, BC.
Roles and Responsibilities:
Leads bispecific antibody drug discovery program to potentiate anti-tumor T cell responses
Designs in vitro and in vivo assays to evaluate immuno-oncology target mechanism-of-action and discover preclinical development candidates
Manages all aspects of antibody drug discovery project execution: including cloning, production/purification, hit antibody discovery screens, in vitro functional evaluation, pharmacology, preliminary manufacturability, PK, and tolerability risk assessment
Provides scientific guidance to immuno-oncology, infectious disease and autoimmunity/inflammation pipelines
Prepares and presents materials for scientific, business, and external meetings
Contributes to patent application filings
Authors study reports and contributes to regulatory document research report generation
May supervise multiple scientific team members
PhD in immunology or related discipline with a minimum of 5 to 8 years’ related experience or an equivalent combination of education and experience
Ideal candidates will have >3 years industrial experience in therapeutic antibody drug discovery
Demonstrated success and technical proficiency in antigen-specific primary human T cell response platforms
Scientific domain expertise in T cell biology, immuno-oncology, and, ideally, infectious disease
Strong organizational skills and the ability to work effectively in a high paced, fast changing environment. Results orientated
Critical observation skills and strong statistical analysis capability
Excellent oral, presentation and scientific/technical writing skills
Proven interpersonal skills with the ability to work collaboratively as a member of cross-functional team. Ability to establish and maintain effective working relationships
Why Work for Us?
Zymeworks’ employees are passionate, engaged and extremely motivated to succeed. We are excited by the cutting-edge of science and technology, the endless possibilities this union holds and the sheer opportunity to be a part of something big. To learn more about Zymeworks Inc. and our current openings, please visit our website at www.zymeworks.com.
We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.