We seek a senior level experienced protein biochemist/enzymologist to make significant contributions to our drug discovery projects. The successful candidate will work with an interdisciplinary team including medicinal chemists, structural biologists and cell biologists to characterize the biochemical properties of lead candidates and lead efforts to elucidate their mechanism of action. He or she will play a key strategic role in identifying techniques and assay formats to profile and characterize small-molecule agents supporting early research and drug discovery programs. Attention to detail and the ability to communicate across multiple scientific disciplines are critical to the role.
Primary responsibilities will include developing and executing biochemical assays for compound profiling as well as selection and characterization of pharmacodynamic markers. Experience in enzyme kinetics, assay development and protein expression is essential. Additional experience in cell biology is a plus. Specific projects will involve collaborative interactions in a multidisciplinary group and across diverse biology areas that target proteins in blood and in other pathways of therapeutic interests.
A Ph.D. in biochemistry, molecular biology or a related discipline, 8+ years of post-degree and industry experience are required.
Detailed knowledge and expertise in enzymology and enzyme-based assay development and optimization
Broad practical experience in characterization of enzymes of different classes, utilizing a variety of enzyme assays and detection technologies.
Expertise and experience with biophysical methods (fluorescence spectroscopy, ITC, DSF) for characterizing molecular interactions and determining affinity and mode of compound binding
Ability to manage, mentor and develop scientists and research associates
Ability to do independent high level problem solving, develop creative strategies to optimize workflow, balance multiple projects and attention to details
Advanced data analysis skills
Excellent writing and verbal communication skills
Ability to work in a collaborative and dynamic environment
Drive, desire, motivation:
Ability to thrive in a fast-paced, entrepreneurial environment with high performing colleagues
Fit with GBT culture:
Ability to build strong relationships with co-workers of various backgrounds and expertise
Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor
Values-based leadership consistent with GBT's
Excitement about the vision and mission of GBT