Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
The Hahn laboratory in the Department of Medical Oncology is seeking applicants for the position of Senior Research Scientist/Project Manager. This individual will work with Dr. Hahn to oversee Project Achilles, a large project (annual budget > $4M) focused on using systematic loss of function genetics to define cancer dependencies and targets. This role will have significant visibility both within DFCI and the Broad Institute as well as with international collaborations. We are seeking an enthusiastic, self-motivated individual with strong interpersonal and writing skills and the ability to work in a fast-paced environment. Position will be located at both Dana-Farber in the Boston Longwood Medical area and at the Broad Institute in Cambridge Kendall Square.
- Coordinates on-going efforts to apply genome scale loss of function approaches to identify cancer vulnerabilities.
- Contributes significantly to the design and execution of research strategies.
- Makes significant contributions to scientific papers; writes and edits reports and papers for presentation or publication.
- Develops and maintains external research networks (Achilles Consortium) to obtain necessary project resources.
- Uses specialized scientific knowledge, experience in genomics, and outstanding technical skills in molecular biology to design and execute wet-lab experiments that support the overall goals of Project Achilles.
- Laboratory methods include but are not limited to: DNA and protein purification, PCR/qPCR, molecular cloning, DNA/PCR product sequencing, SDS PAGE, ChIP, Western and Northern analysis, gel shift assays, lentiviral infections and transformation assays.
- Coordinates Project Achilles with other Broad Cancer Program activities, particular the Cancer Dependency Map Initiative.
- Uses scientific expertise to analyze results and address complex technical problems.
- Consults scientific literature and collaborates with other researchers from the scientific community as needed.
- Interacts with vendors to investigate novel supplies and technologies.
- Recommends revisions in protocols and methodologies and trains lab personnel on new and revised procedures.
- Manages technical staff
- Other responsibilities necessitated by the position or as assigned by the Director, Project Achilles or the Director, Cancer Program
May supervise or mentor junior laboratory personnel.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.
- Ph.D. in molecular biology or related discipline or M.D..
- A minimum of 3 years post Ph.D. or M.D. related experience is required.
- Excellent experimental and analytical skills and ability to solve complex problems.
- Expert technical knowledge with full proficiency in cutting-edge molecular biology methods (cloning, recombinational cloning, PCR), protein analysis, transformation assays, expression and RNA interference.
- Experience in presenting and publishing scientific data and research results.
- Knowledge of various scientific databases
- Ability to set and achieve reasonable goals; experience in lab management, supervision and project management highly desirable
- Excellent communication and organizational skills
- Ability to interact with multidisciplinary scientific staff in a fast-paced environment required.