Senior/Scientist -- PSC and Liver Research - Marlborough, MA | Biospace
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Senior/Scientist -- PSC and Liver Research

Astellas

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Location:
Marlborough, MA
Posted Date:
9/11/2017
Position Type:
Full time
Job Code:
1750041662
Salary:
Required Education:
Doctorate/PhD
Areas of Expertise Desired:
Scientist,

Job Description


Description:

•   The Astellas Institute of Regenerative Medicine (AIRM) is a wholly-owned subsidiary of Astellas Pharma and is focused on the development and commercialization of stem cell and regenerative medicine therapies. Astellas is an R&D-driven global pharmaceutical company whose philosophy is to contribute to the improvement of people's heath around the world through the provision of innovative and reliable pharmaceutical products.

•   Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture. There's something special about working at Astellas. It's reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company.

•   AIRM has a world-class R&D team, and is pursuing a diverse range of disease indications, ranging from macular degeneration (currently in clinical trials) and other ocular indications to vascular and autoimmune disease. AIRM's intellectual property portfolio includes pluripotent stem cell platforms -- both embryonic and induced pluripotent stem cells as well as other cell based therapy research programs. AIRM is headquartered in Marlborough, Massachusetts.

Astellas is announcing a Senior/Scientist -- PSC and Liver Research, located in Marlborough, MA.

Purpose & Scope:

•   Demonstrated potential for creativity and excellence. Candidate will design and conduct novel cell biology and molecular laboratory research and will develop human pluripotent stem cell (PSC)-derived hepatic progenitors for potential clinical applications.

Essential Job Responsibilities:

•   Performs laboratory-based research independently and/or in collaboration with others.
•   Makes detailed observations, analyzes data and interprets results.
•   Exercises technical discretion in the design, execution and interpretation of experiments that contribute to project goals.
•   Prepares technical reports, summaries, protocols, and quantitative analyses. Investigates, creates and develops new methods and technologies for project advancement.
•   Maintains high level of professional expertise through familiarity with scientific literature and novel technologies.
•   Uses professional concepts in accordance with company objectives to solve complex problems in creative and effective ways.

Quantitative Dimensions:

•   This position interacts with all levels of management on a routine basis and influences strategy. Works on complex and diverse problems giving guidance and suggestions. Actions may have implications on operations, budget and/or credibility.

Organizational Context:

Reports to the Sr. Director of Development

Requirements

Requirements:

Qualifications:

Required:

•   We are seeking a PhD (with 2-4 yr of post-doc experience) Scientist/Sr. Scientist Background in liver diseases and liver pathophysiology.
•   Demonstrated industry experience or academic achievement, as evidenced by publications in high impact journals or drug development portfolio
•   Ability to collaborate with external partners across multiple scientific disciplines
•   Excellent written and oral communication skills are essential.

Preferred:

•   Experience with human PSC manipulation.

•   Solid background in endoderm differentiation from human PSCs

•   Expertise on cell lineage characterization using flow cytometry, immunofluorescence, cell isolation using FACS sorting, magnetic beads isolation, RNA seq, etc. are also desirable.

•   Working knowledge of preclinical animal models for liver diseases and liver pathophysiology.

Disclaimer:

•   The statements above are intended to describe the general nature and level of work being performed by people assigned to this classification. They are not to be construed as an exhaustive list of all responsibilities, duties, and skills required of personnel so classified. All personnel may be required to perform duties outside of their normal responsibilities from time to time.

Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled.