Senior Scientist, Protein Engineering - South San Francisco, CA | Biospace
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Senior Scientist, Protein Engineering

Pfizer Inc.

South San Francisco, CA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Areas of Expertise Desired:

Job Description

About Pfizer

A career at Pfizer offers opportunity, ownership and impact. All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Role Description

We are looking for a bench scientist in the field of molecular biology and protein expression and purification. The ideal candidate will have a strong understanding of protein expression in eukaryotic and prokaryotic systems, and extensive experience in cloning techniques essential for protein expression. Individuals who have industrial experience in protein production working in the mg to gram scale are strongly preferred. The successful candidate must be able to work independently and also to be able to lead in lab. Supervisory experience is highly preferred. Experience working with multi-disciplinary teams and the ability to present data in a group setting is required. We are seeking a person who can work within a fluid structure with multiple responsibilities and changing priorities.


The expression of proteins and cloning will be the primary responsibility. It is anticipated that this will require creative, unique approaches, including construct design and screening to increase yields, the development of novel strategies and methods for difficult to express proteins and to increase stability of problematic proteins. The target proteins will be therapeutic proteins, antigens for the generation of therapeutic antibodies, assay reagents for activity screens, and proteins for structural studies. The experience and flexibility to work on downstream purification is a must.



* A minimum of a PhD. in molecular biology or biochemistry with 2-5 years of experience in industry, or equivalent proven expertise. Previous industrial experience strongly preferred, but not required. Emphasis in protein expression in multiple systems, required, with a preference for experience with multiple eukaryotic expression systems including mammalian transient and stable cell lines, and insect cell expression. Experience in prokaryotic systems required.
* Technical expertise should include extensive experience in protein expression, tissue culture, sterile technique, running and maintaining bioreactors, with experience in purification and biophysical and biological characterization a plus.
* Understanding of the biophysics of protein-protein interactions, protein chemistry and extensive experience in the molecular biology and biophysical techniques essential for protein engineering.
* Experience using Wave incubator system preferred. PHYSICAL/MENTAL REQUIREMENTS This is a bench scientist position in the field of molecular biology and protein expression/purification. All the physical requirements for cloning, expressing, and purifying proteins are required.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.