Amgen is seeking a Senior Scientist to join the Pharmacokinetics and Drug Metabolism (PKDM) department at our Kendall Square site in Cambridge, Massachusetts.
In this role you will add to the discovery and non-clinical development of small molecule therapeutics, with a primary focus on drug transporters. You will be responsible for establishing and optimizing in vitro assays to evaluate new chemical entities as substrates or inhibitors of drug transporters in order to assess and characterize the role of transporters in drug disposition. In addition, you will make meaningful and innovative contributions to the fundamental understanding of the role of drug transporters as they relate to absorption, distribution, and clearance of small molecule therapeutics.
In this position your core responsibilities are to:
Serve as a functional representative and subject matter expert on the transport of small molecule therapeutics, collaborating with PBPK scientists across our three-site PKDM scientific community (Cambridge, MA, San Francisco and Thousand Oaks, CA)
Evaluate and implement emerging in vitro and in silico tools to support the prediction of transporter-mediated pharmacokinetics (PK) and drug interactions (DDIs) in humans
Articulate risk and mitigation strategies for human PK and DDI predictions
Design and complete IND and NDA-enabling studies and reports to support regulatory submissions
You will also have opportunities to learn and obtain experience with PKDM strategies for the discovery and non-clinical development of biological therapeutics.
In addition to the core responsibilities, the position provides the opportunity to pursue scientific inquiries into the fundamental physiological and biochemical factors that determine the absorption, distribution, and clearance of protein therapeutics. A collaborative and highly capable scientific community at Amgen is available to support these efforts. Interactions and collaboration with academic and other external scientists is encouraged.
Doctorate degree and 2 years of scientific experience
Master's degree and 5 years of scientific experience
Bachelor's degree and 7 years of scientific experience
A Ph.D. in pharmaceutical, chemical, or biological science
4+ years of drug discovery and/or development experience
Expertise with implementing, optimizing and troubleshooting in vitro transporter assays
Knowledge of PK and distribution of small molecule therapeutics
Critical thinking, and demonstrated ability to communicate with team members across broad disciplines
Effective oral and written communication skills
Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.
Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.