Senior Scientist, Neuroscience Drug Discovery - Carlsbad, CA | Biospace
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Senior Scientist, Neuroscience Drug Discovery

Ionis Pharmaceuticals, Inc.

Carlsbad, CA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Areas of Expertise Desired:
Drug Discovery, Neurosciences, Senior Scientist,

Job Description

Ionis Pharmaceuticals, Inc., located in the North San Diego County city of Carlsbad, was founded in 1989 to create advanced, novel medicines to treat diseases with an unmet medical need. We are the pioneer and leader in the discovery and development of antisense drugs.  By exploiting various cutting-edge RNA targeting technologies, we are capable of specifically and efficiently targeting any gene of interest, including ones which are not targetable by small molecules or antibodies. We currently have two approved drugs, a robust pipeline of over 20 drugs in various stages of clinical trials, and multiple ongoing partnerships with pharmaceutical and biotechnology companies. This strategy provides us with significant financial strength through a continuing stream of revenue from upfront license fees and milestone payments.  

Ionis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence.  Our success is a direct result of our outstanding employees. We are interested in bringing together individuals with different skill sets into this creative environment to be part of a productive team.  Join us and experience our unique culture while you develop and expand your career.


We are seeking a highly qualified individual with relevant experience for a position in our neuroscience drug discovery group who shares the passion of our core principles and culture. Our neuroscience group is working to apply Ionis’ technology to diseases of the central nervous system. We currently have active projects in many neurodegenerative diseases with high unmet medical need.  The candidate will become an integral part of an interdisciplinary team of scientists in the Ionis neuroscience group.


•   Initiating and executing neuroscience drug discovery projects at all stages, including new target identification, preclinical target validation, and drug lead identification for clinical development, with a focus on glial biology and targets.
•   Developing and implementing new assays, including imaging-based assays and cell isolation techniques.



•   Ph.D. in neuroscience or a closely related discipline
•   >4 years of experience in neuroscience research with a proven track record of accomplishments, including publications in top tier scientific journals
•   Research experience in glial biology
•   Experience and expertise in modern laboratory techniques. Specific experience in the following areas would be especially desirable: microscopy, FACS, cell isolation and RNAseq.
•   Direct experience in animal models of pain or brain injury, including neuropathological analyses
•   Experience with small animal surgeries
•   Have strong interpersonal skills including a proven track record of building and maintaining effective working relationships with teams and partners
•   Have the ability to manage multiple assignments effectively in a quickly evolving environment
•   Outstanding communication and team skills
•   Self-starter who is highly motivated and not afraid to take risks

Excellent salary and benefits package offered.

Reference Requisition #17-0053


Ionis Pharmaceuticals, Inc. is proud to be an EEO employer.