Senior Scientist III, Clinical Biomarkers and Companion Diagnostics - South San Francisco, CA | Biospace
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Senior Scientist III, Clinical Biomarkers and Companion Diagnostics

AbbVie Stemcentrx

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Location:
South San Francisco, CA
Posted Date:
6/23/2017
Position Type:
Full time
Job Code:
1703152
Salary:
Required Education:
Bachelors Degree
Areas of Expertise Desired:

Job Description

Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica, Venclexta, and Empliciti — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots wor across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at Stemcentrx, AbbVie’s South San Francisco, CA location.

Specific Job Requirements:

We are seeking a creative and highly motivated scientist to develop and implement biomarker and diagnostic strategies to enable and support the development and commercialization of medically-differentiated therapies in oncology. The Senior Scientist, Clinical Biomarkers and Companion Diagnostics will facilitate the development and execution of specific elements of the biomarker (BM) and companion diagnostic (CDx) strategy for research and development projects. He/she will design, implement and oversee biomarker and diagnostic testing and data analysis for clinical studies. The Senior Scientist will also evaluate the clinical applicability, validation status and any scientific, technical or statistical issues related to BM and CDx assay implementation. He/she will be a point of contact providing help and expert scientific advice related to BM and CDx sample collection, storage and sample and data analysis to other functions (e.g. Contracts, Clinical Operations, Data Management, etc.) to facilitate their interactions with internal and external laboratories. The successful candidate will have the opportunity to work in a highly collaborative environment and will participate as a member of multidisciplinary development project teams.

Essential Duties and Job Functions:


  • Responsible for design, implementation and oversight of biomarker and diagnostic testing in clinical studies and biomarker data analysis

  • Manages the development and validation of clinically applicable BM and CDx assays with external service laboratories

  • Prepares and reviews BM and CDx sections of clinical protocols, ICFs, lab manuals, and clinical study reports

  • Coordinates and monitors BM and CDx sample collection, handling and analysis in clinical studies

  • Collaborates with biostatistics and bioinformatics to design data analysis plans

  • May help design or support research biomarker strategy and assay development
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Requirements

Desired Skills and Experience:


  • PhD in Cancer Biology, Cell Biology, or Molecular Biology or related field and a minimum of 6 years of relevant experience in a pharmaceutical or biotech environment. Must have biomarker expertise in oncology

  • Experience with the discovery, characterization, clinical validation and utilization of innovative biomarkers and potential companion diagnostics

  • Experience in development, outsourcing and validation of clinically applicable BM and CDx assays

  • Excellent verbal communication and interpersonal skills are required

  • Must be able to multi-task and work effectively within a team environment

  • Strong motivation, attention to detail, ability to think independently and fully integrate into a high achieving team environment