Senior Scientist I, Target Biology - 1721 - San Diego, CA | Biospace
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Senior Scientist I, Target Biology - 1721

AnaptysBio, Inc.

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Location:
San Diego, CA
Posted Date:
9/21/2017
Position Type:
Full time
Job Code:
Salary:
Required Education:
Doctorate/PhD
Areas of Expertise Desired:
Biology, Scientist Biology, Senior Scientist,

Job Description


Position Summary  

This position is focused on target identification, target validation, and mechanism-of-action studies  to support inflammation and immuno-oncology projects using public literature,  public gene expression and SNP datasets as well as in-house data.  In addition, this position will work closely with translational medicine to validate target-to-disease linkages and identify disease-associated biomarkers for new and existing projects.  Will also use computational biology and bioinformatics tools to analyze  gene expression profiling and next generation sequencing. This position works in a matrix environment with molecular biologists, cell biologists, protein scientists and external collaborators.

Essential Functions  

•   Apply comprehensive literature surveys and meta-analysis of published studies on biological targets and pathways to support target identification
•   Present therapeutic antibody concepts, rationales, target validation plans, target product profiles, and project plans to research leadership teams
•   Use computational tools to analyze and interpret data from public genomic, transcriptomic, and proteomic datasets and in-house studies to support target validation and prioritization, clinical development, and data-driven decision making across therapeutic programs
•   Use computational tools to identify and study novel therapeutic targets and pathway analysis tools to assist in elucidating the mechanisms of action of ongoing and new projects
•   Identify biomarkers to support molecular and genetic-based patient selection criteria in the early clinical development phase
•   Participate in the planning and execution of collaborative projects with CROs and academic research groups
•   Contribute major sections of internal and external reports and patent applications.
•   May lead projects, including effectively leading cross-functional teams in the implementation of the company platform technologies, determining project strategy and key experiments, analyzing and interpreting data, and preparing associated documentation.

Requirements


Education & Experience:


•   Ph.D. in immunology, biochemistry, molecular biology or related discipline, and 5+ years of post-doctoral or industry experience.
•   Experience in immunology, cell biology, pathway analysis, and biostatistics
•   Extensive experience in designing new drug concepts, developing project plans for early drug concept validation, and project team leadership
•   Some experience using computational tools to analyze genomic, proteomic, and transcriptomic data  
•   Experience with deep sequencing of antibody  repertoires a plus

Additional Responsibilities:  

•   Writes and reviews manuscripts, grants, and intellectual property documents
•   Designs antigens, recombined antibodies, secondary reagents and antibody libraries
•   Performs additional bioinformatics and computational biology to include:
     o   Data mining and statistics of somatic hypermutation data and public antibody repertoire data
     o   Protein modeling, graphics and design
•   Manages projects with the goal of rapid identification of superior therapeutic candidates, to include:
     o   Coordinates activities for representatives of Molecular Biology, Cellular Biology,  and Protein Sciences
     o   Runs project teams meetings
     o   Writes project reports and leads exhaustive program reviews
     o   Performs and communicates background research within the therapeutic/project area:
              o      Intellectual propery, Target Biology, competitive landscape, bioassays and animal models, and design goals
     o   Presents data, conclusions and potential strategies to senior management
•   Provide performance reviews, feedback and career development for subordinates

Personal Competencies:

•   Ability to communicate clearly, and to report and present experimental results and analysis to colleagues and management.
•   Effective interpersonal skills, including both written and oral communication skills.
•   Ability to work effectively in as a team player in a complex, changing environment.
•   Highly self-motivated and results-oriented, with the capacity to organize assignments, and work within deadlines.
•   Able to successfully work both independently and as a team member in a dynamic, fast-paced environment, committed to success and getting the job done.
•   Ability to function in a fast-paced entrepreneurial environment.
•   Ability to work independently while also willing to follow protocols.
•   Strong analytical and organizational skills.
•   Highly attentive to details.


Other Information

•   Position may require occasional evening and/or weekend commitment
•   Position may require working with biological and/or chemical hazards
•   Position might require lifting up to 20 pounds