Senior Scientist I/II, Oncology - South San Francisco, CA | Biospace
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Senior Scientist I/II, Oncology

CytomX Therapeutics, Inc.

South San Francisco, CA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Areas of Expertise Desired:
Oncology, Senior Scientist,

Job Description

CytomX Therapeutics is unlocking the potential of antibody therapeutics in oncology by developing a novel therapeutic antibody class of highly targeted Probody™ therapeutics. The current opening offers an opportunity to participate in moving novel Probody Therapeutics toward clinical investigation in a fast-moving and dynamic R&D environment.

We seek a highly-motivated individual to characterize oncology targets and evaluate Probody or Probody drug conjugates (PDCs) for the treatment of cancer. The successful candidate will participate in efforts supporting pre-clinical development of therapeutic Probodies from target identification to IND submission.


•   Drive the Oncology pipeline forward by identifying novel targets and evaluating next generation of linker payloads for the development of PDCs
•   Apply biochemical, molecular and functional assays to characterize Probodies in a variety of in vivo and cell-based systems
•   Design efficacy and tox studies
•   Work with vendors and CROs to run studies as well as generate reagents
•   Keep accurate and up-to-date records, communicate results and propose scientifically based recommendations



•   Ph.D. in cell biology, biochemistry, immunology, molecular biology or related field
•   At least 5-7 years of relevant industry experience in oncology drug development is required
•   3+ years supervisory experience strongly preferred
•   Experience with ADCs is strongly preferred
•   Experience in protein engineering is strongly preferred
•   Skilled at independently developing immunization and screening strategies to discover custom antibodies for ELISA, western blot, immunoprecipitation assays, IHC and other reagent generation
•   A demonstrated track record of independent critical thinking and scientific achievement in oncology
•   Experience leading projects and working with cross-functional teams
•   Must have outstanding communication (oral and written) and presentation skills and will present project updates to Senior Management, partners as well as wider audiences
•   Ability to lead teams in a cross-functional work environment is critical
•   Strong leadership skills and ability to work independently are expected

CytomX is an equal opportunity employer. Employment decisions are based on merit and business needs. CytomX will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.